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QuickView for Isopropamide (compound)


PubChem
Name: isopropamide iodide
PubChem Compound ID: 3775
Molecular formula: C23H33N2O+
Molecular weight: 353.521 g/mol
Synonyms:
Isamid; Sanulcin; DivK1c_000240; Spectrum_000203; Tyrimide; Chloroisopropamide; NCGC00016308-01; C07055; Spectrum2_001051; NSC15548.
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DrugBank
Identification
Name: isopropamide iodide
Name (isomeric): DB01625
Drug Type: small molecule
Synonyms:
2,2-Diphenyl-4-diisopropylaminobutyramide methiodide; Isopropamide iodide; Isoproponum iodide; 4-(Diisopropylamino)-2,2-diphenylbutyramide methiodide; Chloroisopropamide
Brand: Dipramide, Priazimide, Isamid, Darbid, Sanulcin, Piaccamide, Tyrimide, Priamide, Marygin-M, Dipramid
Category: Gastrointestinal Agents
CAS number: 7492-32-2
Pharmacology
Indication: For the treatment of a wide range of gastrointestinal disorders, including such conditions as peptic ulcer, gastritis, hyperchlorhydria, functional diarrhea, irritable or spastic colon, pyloroduodenal irritability, pylorospasm, acute nonspecific gastroenteritis, biliary dyskinesia and chronic cholelithiasis, duodenitis, gastrointestinal spasm; it may also be used to treat genitourinary spasm.
Pharmacology: Isopropamide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
Mechanism of Action:
Anticholinergics are a class of medications that inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells. The nerve fibers of the parasympathetic system are responsible for the involuntary movements of smooth muscles present in the gastrointestinal tract. Inhibi...
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Toxicity: Symptoms of overdose include dryness of mouth, dysphagia, thirst, blurred vision, dilated pupils, photophobia, fever, rapid pulse and respiration, disorientation. Depression and circulatory collapse may result from severe overdosage.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
DonepezilPossible antagonism of action
HaloperidolThe anticholinergic increases the risk of psychosis and tardive dyskinesia
GalantaminePossible antagonism of action

Targets