QuickView for JAG1 (gene)

Gene Symbol:

JAG1 Homo sapiens

Full name:

jagged 1

Synonyms:

AGS, AGS1, AHD, AWS, CD339, HJ1, JAGL1, protein jagged-1

Genomic Location:

Chr 20: 10566334-10602590

Description:

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play...

View Full Description

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  ATAAGCT_MIR21 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TTTGCAG_MIR518A2 ,  ARNT_01 ,  GCANCTGNY_MYOD_Q6 ,  CTATGCA_MIR153 ,  TGTGTGA_MIR377 ,  ATF4_Q2 ,  HP1SITEFACTOR_Q6 ,  TACTTGA_MIR26A_MIR26B ,  CTTTGA_LEF1_Q2 ,  CREB_Q4 ,  WHN_B ,  CREB_Q3 ,  MYAATNNNNNNNGGC_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  TFIII_Q6 ,  TGTATGA_MIR4853P ,  GGGYGTGNY_UNKNOWN ,  CAGGTA_AREB6_01 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  TGCCTTA_MIR124A ,  ATTCTTT_MIR186 ,  GCAAAAA_MIR129 ,  GGGCGGR_SP1_Q6 ,  ACTGCCT_MIR34B ,  OCT1_03 ,  YTTCCNNNGGAMR_UNKNOWN ,  NERF_Q2 ,  TAATAAT_MIR126 ,  POU1F1_Q6 ,  TGTTTGY_HNF3_Q6 ,  TAXCREB_02 ,  NRF1_Q6 ,  AHRARNT_01 ,  AREB6_03 ,  GTGCCTT_MIR506 ,  OCT1_02 ,  TTGTTT_FOXO4_01 ,  SCGGAAGY_ELK1_02 ,  HEN1_02 ,  CREB_Q2 ,  IK3_01 ,  PAX_Q6 ,  RCGCANGCGY_NRF1_Q6 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  GGCKCATGS_UNKNOWN ,  FOXO4_02 ,  LMO2COM_01 ,  TCF11_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-421 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-496

View More

View Less

Cytogenetic Map:

20p12.2

search → result