QuickView for JAK1 (gene)
- Gene Symbol:
- JAK1
Homo sapiens - Full name:
- Janus kinase 1
- Synonyms:
- JAK1A, JAK1B, JTK3, tyrosine-protein kinase JAK1
- Genomic Location:
- Chr 1: 65071494-65204775
- Description:
-
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interfer...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1p31.3
| Transcripts Names |
|---|
| NM_002227 |
| NM_001321857 |
| NM_001321856 |
| NM_001321855 |
| NM_001321853 |
| NM_001321854 |
| NM_001321852 |
| NM_001320923 |
GO Molecular Function
guanyl-nucleotide exchange factor activity | GTPase binding | cation binding | hormone receptor binding | CCR chemokine receptor binding | enzyme binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | Ras GTPase binding | molecular function regulator | catalytic activity | ATP binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | growth hormone receptor binding | purine nucleotide binding | ion binding | chemokine receptor binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | protein phosphatase binding | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | G-protein coupled receptor binding | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | transferase activity | small GTPase binding | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | CCR5 chemokine receptor binding | drug binding | kinase activity | phosphatase binding | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
interleukin-2-mediated signaling pathway | guanyl-nucleotide exchange factor activity | response to cytokine | interleukin-6-mediated signaling pathway | intracellular signal transduction | cellular response to interleukin-2 | peptidyl-amino acid modification | cellular response to type I interferon | regulation of immune system process | positive regulation of developmental process | defense response | regulation of sprouting angiogenesis | interleukin-7-mediated signaling pathway | peptidyl-tyrosine phosphorylation | response to antibiotic | regulation of response to interferon-gamma | cellular process | response to type I interferon | regulation of response to cytokine stimulus | regulation of angiogenesis | regulation of immune response | regulation of cellular process | interferon-gamma-mediated signaling pathway | regulation of interferon-gamma-mediated signaling pathway | MAPK cascade | cellular response to interferon-gamma | regulation of vasculature development | response to stimulus | signal transduction by protein phosphorylation | response to stress | positive regulation of sprouting angiogenesis | interleukin-9-mediated signaling pathway | protein modification process | response to interleukin-12 | interleukin-12-mediated signaling pathway | macromolecule modification | molecular function regulator | cellular response to interleukin-6 | nitrogen compound metabolic process | regulation of signal transduction | phosphorus metabolic process | response to interleukin-2 | cytokine-mediated signaling pathway | cellular response to interleukin-7 | cellular response to cytokine stimulus | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cytokine-mediated signaling pathway | protein tyrosine kinase activity | interleukin-15-mediated signaling pathway | response to interleukin-15 | protein metabolic process | response to organic substance | regulation of innate immune response | response to interleukin-9 | cell surface receptor signaling pathway | interleukin-21-mediated signaling pathway | metabolic process | Ras guanyl-nucleotide exchange factor activity | immune response | protein kinase activity | organic substance metabolic process | response to interferon-gamma | interleukin-27-mediated signaling pathway | type I interferon signaling pathway | non-membrane spanning protein tyrosine kinase activity | regulation of cell communication | signaling | interleukin-35-mediated signaling pathway | cellular protein metabolic process | regulation of developmental process | kinase activity | cellular protein modification process | innate immune response | immune system process | cellular metabolic process | cellular response to organic substance | response to interleukin-6 | positive regulation of angiogenesis | signal transduction | regulation of signaling | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | adherens junction | focal adhesion | cytoplasmic vesicle | cell | cytoplasm | cell-substrate junction | intracellular organelle | endomembrane system | vesicle | endosome | membrane-bounded organelle | nucleus | organelle | cell-substrate adherens junction | cytosol | intracellular vesicle | cytoskeleton | intracellular | cell junction
