QuickView for JAK3;jsessionid=FCEDDC0DB34DE95BDC07932FCE6BFE59 (gene)
- Gene Symbol:
- JAK3
Homo sapiens - Full name:
- Janus kinase 3
- Synonyms:
- JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK, tyrosine-protein kinase JAK3, Janus kinase 3 (a protein tyrosine kinase, leukocyte), leukocyte Janus kinase
- Genomic Location:
- Chr 19: 17797961-17819800
- Description:
-
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Bos taurus , Danio rerio , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
RYTTCCTG_ETS2_B , NFKAPPAB_01 , NFKAPPAB65_01 , MSX1_01 , CREL_01 , STAT1_01 , NFKB_Q6_01 , NFKB_Q6 , NFKB_C , GGGNNTTTCC_NFKB_Q6_01
- Cytogenetic Map:
-
19p13.11
GO Molecular Function
guanyl-nucleotide exchange factor activity | GTPase binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | Ras GTPase binding | molecular function regulator | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | protein phosphatase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | transferase activity | small GTPase binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding
GO Biological Process
negative regulation of lymphocyte differentiation | leukocyte homeostasis | negative regulation of leukocyte activation | adaptive immune response | interleukin-2-mediated signaling pathway | negative regulation of immune system process | guanyl-nucleotide exchange factor activity | response to cytokine | intracellular signal transduction | regulation of programmed cell death | cellular response to interleukin-2 | peptidyl-amino acid modification | erythrocyte homeostasis | regulation of immune system process | response to hormone | myeloid cell differentiation | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of lymphocyte activation | cell differentiation | regulation of T cell differentiation | JAK-STAT cascade | response to growth hormone | positive regulation of cell adhesion | interleukin-7-mediated signaling pathway | peptidyl-tyrosine phosphorylation | B cell differentiation | negative regulation of T-helper 1 cell differentiation | cellular process | lymphocyte differentiation | immune system development | negative regulation of alpha-beta T cell differentiation | negative regulation of apoptotic process | cellular response to growth hormone stimulus | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cell differentiation | negative regulation of CD4-positive, alpha-beta T cell activation | regulation of lymphocyte apoptotic process | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | cellular response to organonitrogen compound | MAPK cascade | response to stimulus | regulation of glycoprotein biosynthetic process | negative regulation of T cell apoptotic process | positive regulation of immune system process | signal transduction by protein phosphorylation | negative regulation of cell adhesion | regulation of CD4-positive, alpha-beta T cell activation | negative regulation of lymphocyte activation | positive regulation of lymphocyte proliferation | regulation of cell proliferation | response to peptide | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of T cell activation | interleukin-9-mediated signaling pathway | negative regulation of metabolic process | hemopoiesis | negative regulation of hemopoiesis | protein modification process | regulation of cell adhesion | macromolecule modification | molecular function regulator | regulation of lymphocyte differentiation | negative regulation of adaptive immune response | myeloid cell homeostasis | leukocyte differentiation | response to nitrogen compound | cellular response to hormone stimulus | positive regulation of mononuclear cell proliferation | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of T-helper cell differentiation | multicellular organism development | cellular response to peptide hormone stimulus | phosphorus metabolic process | regulation of CD4-positive, alpha-beta T cell differentiation | response to interleukin-2 | regulation of T cell activation | cellular response to peptide | negative regulation of cytokine production | regulation of lymphocyte activation | negative regulation of lymphocyte apoptotic process | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | enzyme linked receptor protein signaling pathway | cytokine-mediated signaling pathway | negative regulation of FasL biosynthetic process | cellular response to interleukin-7 | homeostasis of number of cells | cellular response to cytokine stimulus | B cell activation | negative regulation of interleukin-12 production | negative regulation of T-helper 1 type immune response | positive regulation of T cell proliferation | negative regulation of immune response | phosphorylation | JAK-STAT cascade involved in growth hormone signaling pathway | protein phosphorylation | phosphate-containing compound metabolic process | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of alpha-beta T cell differentiation | lymphocyte homeostasis | negative regulation of cell activation | regulation of T cell apoptotic process | regulation of cytokine production involved in immune response | regulation of protein metabolic process | homeostatic process | positive regulation of cell proliferation | negative regulation of CD4-positive, alpha-beta T cell differentiation | negative regulation of T cell differentiation | lymphocyte activation | protein tyrosine kinase activity | negative regulation of thymocyte apoptotic process | interleukin-15-mediated signaling pathway | cellular response to interleukin-4 | response to interleukin-15 | protein metabolic process | response to organic substance | regulation of hemopoiesis | regulation of JAK-STAT cascade | regulation of intracellular signal transduction | response to interleukin-9 | anatomical structure development | cell surface receptor signaling pathway | interleukin-4-mediated signaling pathway | interleukin-21-mediated signaling pathway | metabolic process | regulation of adaptive immune response | regulation of thymocyte apoptotic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | Ras guanyl-nucleotide exchange factor activity | negative regulation of glycoprotein metabolic process | immune response | protein kinase activity | organic substance metabolic process | negative regulation of biosynthetic process | animal organ development | regulation of cell activation | regulation of dendritic cell cytokine production | T cell homeostasis | cell activation | regulation of T-helper cell differentiation | negative regulation of protein metabolic process | regulation of cell communication | regulation of T-helper 1 cell differentiation | signaling | regulation of T cell proliferation | growth hormone receptor signaling pathway | negative regulation of leukocyte apoptotic process | cellular protein metabolic process | regulation of cytokine production | tyrosine phosphorylation of STAT protein | regulation of developmental process | kinase activity | developmental process | erythrocyte differentiation | cellular protein modification process | negative regulation of alpha-beta T cell activation | regulation of cell-cell adhesion | negative regulation of dendritic cell cytokine production | response to organonitrogen compound | transmembrane receptor protein tyrosine kinase signaling pathway | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | negative regulation of cell death | positive regulation of leukocyte cell-cell adhesion | negative regulation of cell differentiation | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | negative regulation of interleukin-10 production | response to interleukin-4
GO Cellular Component
cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | endomembrane system | plasma membrane | vesicle | endosome | membrane-bounded organelle | organelle | cell periphery | cytosol | intracellular vesicle | cytoskeleton | intracellular | membrane
