QuickView for JAM1 (gene)

Gene Symbol:

F11R Homo sapiens

Full name:

F11 receptor

Synonyms:

CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1, junctional adhesion molecule A, junctional adhesion molecule 1, platelet F11 receptor, platelet adhesion molecule 1

Genomic Location:

Chr 1: 159232608-159275358

Description:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of...

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Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SRY_01 ,  CACCCBINDINGFACTOR_Q6 ,  TGCCTTA_MIR124A ,  TTGTTT_FOXO4_01 ,  SCGGAAGY_ELK1_02 ,  HEN1_02 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  LBP1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-29

miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes

Cytogenetic Map:

1q23.3

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