QuickView for Jak2 (gene)
- Gene Symbol:
- JAK2
Homo sapiens - Full name:
- Janus kinase 2
- Synonyms:
- JTK10, THCYT3, tyrosine-protein kinase JAK2, JAK-2, Janus kinase 2 (a protein tyrosine kinase)
- Genomic Location:
- Chr 9: 4975245-5117995
- Description:
-
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with t...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
9p24.1
| Transcripts Names |
|---|
| NM_004972 |
| NM_001322195 |
| NM_001322194 |
| NM_001322204 |
| NM_001322199 |
| NM_001322198 |
| NM_001322196 |
GO Molecular Function
phosphatidylinositol 3-kinase binding | guanyl-nucleotide exchange factor activity | kinase binding | histone kinase activity (H3-Y41 specific) | cofactor binding | GTPase binding | cation binding | hormone receptor binding | protein kinase binding | type 1 angiotensin receptor binding | enzyme binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | Ras GTPase binding | molecular function regulator | catalytic activity | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | growth hormone receptor binding | purine nucleotide binding | identical protein binding | angiotensin receptor binding | ion binding | organic cyclic compound binding | peptide hormone receptor binding | purine ribonucleoside triphosphate binding | tetrapyrrole binding | protein tyrosine kinase activity | protein binding | histone kinase activity | transferase activity, transferring phosphorus-containing groups | G-protein coupled receptor binding | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | transferase activity | histone binding | small GTPase binding | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | heme binding | growth factor receptor binding | drug binding | kinase activity | insulin receptor substrate binding | metal ion binding | heterocyclic compound binding | acetylcholine receptor binding | protein C-terminus binding | small molecule binding | interleukin-12 receptor binding | SH2 domain binding
GO Biological Process
positive regulation of smooth muscle cell proliferation | positive regulation of skeletal muscle cell proliferation | regulation of interleukin-1 beta production | adaptive immune response | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | regulation of dephosphorylation | regulation of intracellular protein transport | actin filament-based process | guanyl-nucleotide exchange factor activity | response to cytokine | response to lipopolysaccharide | regulation of cellular localization | interleukin-6-mediated signaling pathway | intracellular signal transduction | positive regulation of apoptotic process | positive regulation of skeletal muscle satellite cell proliferation | histone kinase activity (H3-Y41 specific) | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | erythrocyte homeostasis | actin cytoskeleton organization | regulation of immune system process | response to hormone | myeloid cell differentiation | positive regulation of phosphoprotein phosphatase activity | regulation of nitric oxide biosynthetic process | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | regulation of phosphatase activity | cellular response to tumor necrosis factor | histone modification | regulation of protein import | regulation of cardiac muscle cell apoptotic process | cell differentiation | JAK-STAT cascade | defense response | nervous system development | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | response to growth hormone | cellular chemical homeostasis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | positive regulation of cellular component movement | regulation of peptide hormone secretion | generation of neurons | positive regulation of protein secretion | response to antibiotic | regulation of response to interferon-gamma | hormone-mediated signaling pathway | positive regulation of vascular smooth muscle cell proliferation | regulation of neuron death | positive regulation of dephosphorylation | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | cellular homeostasis | extrinsic apoptotic signaling pathway | chromatin organization | neuron development | positive regulation of reactive oxygen species metabolic process | mesoderm development | immune system development | regulation of skeletal muscle cell proliferation | positive regulation of protein kinase activity | regulation of response to cytokine stimulus | hemostasis | negative regulation of apoptotic process | regulation of proteolysis | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | cellular response to growth hormone stimulus | positive regulation of epithelial cell apoptotic process | response to peptide hormone | tissue development | regulation of binding | regulation of cell differentiation | intrinsic apoptotic signaling pathway | regeneration | regulation of immune response | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | interferon-gamma-mediated signaling pathway | regulation of cytosolic calcium ion concentration | regulation of interferon-gamma-mediated signaling pathway | regulation of skeletal muscle satellite cell proliferation | positive regulation of cellular protein metabolic process | epithelium development | cellular response to organonitrogen compound | cellular component organization | MAPK cascade | calcium ion homeostasis | cellular response to interferon-gamma | positive regulation of tumor necrosis factor production | histone H3-Y41 phosphorylation | regulation of peptide secretion | response to stimulus | positive regulation of interleukin-1 beta production | regulation of cellular protein localization | positive regulation of cold-induced thermogenesis | regulation of peptidyl-tyrosine phosphorylation | positive regulation of nitric oxide metabolic process | regulation of insulin secretion | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | negative regulation of cell adhesion | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | positive regulation of JAK-STAT cascade | positive regulation of cellular protein localization | regulation of cell proliferation | regulation of blood circulation | response to peptide | positive regulation of cysteine-type endopeptidase activity | programmed cell death | positive regulation of phosphatase activity | supramolecular fiber organization | positive regulation of cell activation | positive regulation of proteolysis | response to molecule of bacterial origin | actin filament polymerization | positive regulation of hormone secretion | regulation of DNA binding | cellular response to organic cyclic compound | regulation of protein transport | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | G-protein coupled receptor signaling pathway | positive regulation of protein serine/threonine kinase activity | hemopoiesis | cellular component assembly | protein modification process | steroid hormone mediated signaling pathway | regulation of peptide transport | regulation of cell adhesion | response to interleukin-12 | interleukin-12-mediated signaling pathway | macromolecule modification | positive regulation of protein dephosphorylation | activation of protein kinase activity | regulation of intracellular transport | molecular function regulator | metal ion homeostasis | myeloid cell homeostasis | blood coagulation | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of neurotransmitter levels | response to nitrogen compound | negative regulation of neuron apoptotic process | apoptotic process | cellular response to interleukin-6 | cellular response to hormone stimulus | positive regulation of reactive oxygen species biosynthetic process | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | cellular response to peptide hormone stimulus | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | negative regulation of striated muscle cell apoptotic process | actin filament organization | mammary gland development | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | cellular response to oxidative stress | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | wound healing | regulation of gene expression | platelet-derived growth factor receptor signaling pathway | axon development | positive regulation of secretion | cellular response to stress | response to lipid | cellular response to peptide | positive regulation of intracellular protein transport | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | response to axon injury | regulation of protein localization to nucleus | positive regulation of cytosolic calcium ion concentration | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | actin polymerization or depolymerization | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of STAT cascade | cytokine-mediated signaling pathway | protein polymerization | positive regulation of intracellular signal transduction | negative regulation of DNA binding | regulation of cellular component movement | response to oxidative stress | negative regulation of binding | positive regulation of hydrolase activity | positive regulation of cell differentiation | homeostasis of number of cells | positive regulation of growth hormone receptor signaling pathway | positive regulation of cell migration | negative regulation of cardiac muscle cell apoptotic process | cellular response to cytokine stimulus | positive regulation of protein localization to nucleus | neuron projection regeneration | regulation of cellular protein metabolic process | phosphorylation | positive regulation of endopeptidase activity | cellular protein-containing complex assembly | mineralocorticoid receptor signaling pathway | JAK-STAT cascade involved in growth hormone signaling pathway | regulation of apoptotic signaling pathway | regulation of heart contraction | regulation of epithelial cell apoptotic process | protein phosphorylation | regulation of tumor necrosis factor production | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | phosphate-containing compound metabolic process | response to bacterium | regulation of interleukin-1 production | negative regulation of cell-cell adhesion | regulation of muscle cell apoptotic process | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | positive regulation of interleukin-1 production | positive regulation of tyrosine phosphorylation of STAT protein | positive regulation of growth factor dependent skeletal muscle satellite cell proliferation | activation of MAPKK activity | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of locomotion | regulation of RNA metabolic process | histone phosphorylation | positive regulation of transport | positive regulation of peptide hormone secretion | coagulation | apoptotic signaling pathway | intrinsic apoptotic signaling pathway in response to oxidative stress | protein tyrosine kinase activity | positive regulation of molecular function | regulation of nucleocytoplasmic transport | neuron differentiation | protein-containing complex assembly | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | gland development | regulation of innate immune response | positive regulation of insulin secretion | regulation of protein import into nucleus | activation of Janus kinase activity | histone kinase activity | regulation of protein dephosphorylation | regulation of JAK-STAT cascade | regulation of kinase activity | response to wounding | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of programmed cell death | negative regulation of heart contraction | negative regulation of muscle cell apoptotic process | chemical homeostasis | Ras guanyl-nucleotide exchange factor activity | regulation of secretion | positive regulation of cell death | immune response | protein kinase activity | neuron projection development | organic substance metabolic process | interleukin-23-mediated signaling pathway | cell death | animal organ development | positive regulation of cell-substrate adhesion | regulation of cell activation | regulation of protein secretion | positive regulation of programmed cell death | positive regulation of kinase activity | tumor necrosis factor-mediated signaling pathway | ion homeostasis | regulation of phosphate metabolic process | cytoskeleton organization | mammary gland epithelium development | cellular response to steroid hormone stimulus | positive regulation of binding | response to interferon-gamma | positive regulation of cytokine production | positive regulation of intracellular transport | positive regulation of MAPK cascade | intracellular receptor signaling pathway | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | interleukin-27-mediated signaling pathway | non-membrane spanning protein tyrosine kinase activity | positive regulation of protein import into nucleus, translocation | regulation of cell communication | negative regulation of molecular function | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | response to organic cyclic compound | interleukin-35-mediated signaling pathway | cell development | positive regulation of DNA binding | growth hormone receptor signaling pathway | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | regulation of endopeptidase activity | positive regulation of MAP kinase activity | positive regulation of protein import into nucleus | response to biotic stimulus | axon regeneration | tyrosine phosphorylation of STAT protein | regulation of developmental process | cell death in response to oxidative stress | regulation of phosphoprotein phosphatase activity | kinase activity | developmental process | organelle organization | erythrocyte differentiation | positive regulation of protein import | response to hydroperoxide | intracellular steroid hormone receptor signaling pathway | cellular protein modification process | regulation of transport | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | innate immune response | response to organonitrogen compound | cellular metal ion homeostasis | positive regulation of nitric oxide biosynthetic process | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | chromosome organization | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to steroid hormone | response to interleukin-6 | negative regulation of cell death | regulation of inflammatory response | divalent inorganic cation homeostasis | positive regulation of nucleocytoplasmic transport | positive regulation of apoptotic signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of nitric-oxide synthase biosynthetic process | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | adherens junction | focal adhesion | cytoplasmic vesicle | cell | nuclear lumen | cytoplasm | cell-substrate junction | intracellular organelle | membrane microdomain | endomembrane system | nucleoplasm | plasma membrane | membrane raft | vesicle | endosome | membrane-bounded organelle | endosome lumen | nucleus | organelle | cell periphery | membrane-enclosed lumen | cell-substrate adherens junction | nuclear matrix | plasma membrane raft | cytosol | intracellular vesicle | cytoskeleton | intracellular | cell junction | caveola | membrane | nuclear periphery
