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QuickView for Josamycin (compound)


PubChem
Name: Josamycin
PubChem Compound ID: 3804
Description: A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.
Molecular formula: C42H69NO15
Molecular weight: 827.995 g/mol
DrugBank
Identification
Name: Josamycin
Name (isomeric): DB01321
Drug Type: small molecule
Description: A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.
Synonyms:
JM; Leucomycin V, 3-acetate 4B-(3-methylbutanoate); Josamycine [inn-french]; Josamicina [inn-spanish]; Leucomycin V, 3-acetate 4(sup beta)-(3-methylbutanoate); Antibiotic yl-704 A3; Leucomycin V, 3-acetate 4(sup B)-(3-methylbutanoate); Leucomycin A3; Josamycinum [inn-latin]
Brand: Kitasamycin A3, Turimycin A5, Josacine
Category: Anti-Bacterial Agents, Antibacterial Agents, Macrolides
CAS number: 16846-24-5
Pharmacology
Indication: For the treatment of bacterial infections.
Pharmacology: Josamycin is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.
Mechanism of Action:
The mechanism of action of macrolides such as Josamycin is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA. This action is mainly bacteriostatic, but can also be bactericidal in high concentrations. Macrolides tend to accumulate wi...
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Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
GrepafloxacinIncreased risk of cardiotoxicity and arrhythmias
ItraconazoleThe macrolide, josamycin, may increase the effect and toxicity of itraconazole.
LevofloxacinIncreased risk of cardiotoxicity and arrhythmias
DigoxinThe macrolide, josamycin, may increase the effect of digoxin in 10% of patients.
CyclosporineThe macrolide, josamycin, may increase the effect of cyclosporine.
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Targets


Enzymes