Name: | Josamycin |
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PubChem Compound ID: | 3804 |
Description: | A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens. |
Molecular formula: | C42H69NO15 |
Molecular weight: | 827.995 g/mol |
Name: | Josamycin |
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Name (isomeric): | DB01321 |
Drug Type: | small molecule |
Description: | A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens. |
Synonyms: |
JM; Leucomycin V, 3-acetate 4B-(3-methylbutanoate); Josamycine [inn-french]; Josamicina [inn-spanish]; Leucomycin V, 3-acetate 4(sup beta)-(3-methylbutanoate); Antibiotic yl-704 A3; Leucomycin V, 3-acetate 4(sup B)-(3-methylbutanoate); Leucomycin A3; Josamycinum [inn-latin]
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Brand: | Kitasamycin A3, Turimycin A5, Josacine |
Category: | Anti-Bacterial Agents, Antibacterial Agents, Macrolides |
CAS number: | 16846-24-5 |
Indication: | For the treatment of bacterial infections. |
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Pharmacology: | Josamycin is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens. |
Mechanism of Action: |
The mechanism of action of macrolides such as Josamycin is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA. This action is mainly bacteriostatic, but can also be bactericidal in high concentrations. Macrolides tend to accumulate wi...
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Affected organisms: | Enteric bacteria and other eubacteria |
Drug interaction: |
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