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QuickView for KALRN;jsessionid=851C9E7D347AA3D49E84C243D61FDCA6 (gene)


Gene Symbol:
KALRN Homo sapiens Homo sapiens
Full name:
kalirin RhoGEF kinase
Synonyms:
ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD, kalirin, huntingtin-associated protein interacting protein (duo), serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Genomic Location:
Chr 3: 125296275-125922726
Description:
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3
3q21.1-q21.2





GO Molecular Function

Rho guanyl-nucleotide exchange factor activity | guanyl-nucleotide exchange factor activity | enzyme activator activity | GTPase binding | Rho GTPase binding | cation binding | GTPase activator activity | enzyme binding | ribonucleotide binding | nucleotide binding | GTPase regulator activity | carbohydrate derivative binding | protein serine/threonine kinase activity | Ras GTPase binding | molecular function regulator | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | Rac GTPase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | transferase activity | small GTPase binding | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | Rac guanyl-nucleotide exchange factor activity | heterocyclic compound binding | small molecule binding

GO Biological Process

behavioral response to pain | Rho guanyl-nucleotide exchange factor activity | chemosensory behavior | guanyl-nucleotide exchange factor activity | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | behavioral fear response | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | enzyme activator activity | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of programmed cell death | establishment of localization | negative regulation of cellular process | positive regulation of developmental process | social behavior | regulation of protein localization to membrane | cell differentiation | defense response | nervous system development | response to drug | neurogenesis | regulation of peptide hormone secretion | generation of neurons | positive regulation of dendritic spine morphogenesis | behavioral response to formalin induced pain | positive regulation of GTPase activity | cellular process | secretion | regulation of dendritic spine morphogenesis | localization | positive regulation of synaptic transmission | regulation of growth hormone secretion | negative regulation of signaling | regulation of neuronal synaptic plasticity | habituation | multicellular organismal reproductive process | GTPase activator activity | learning | negative regulation of secretion | positive regulation of catalytic activity | regulation of neuron projection development | negative regulation of hormone secretion | regulation of cell differentiation | regulation of cellular process | parturition | regulation of apoptotic process | small GTPase mediated signal transduction | ephrin receptor signaling pathway | cellular component organization | positive regulation of dendrite morphogenesis | regulation of peptide secretion | response to stimulus | maternal behavior | regulation of cellular protein localization | regulation of long-term synaptic potentiation | response to pain | response to cocaine | GTPase regulator activity | response to stress | negative regulation of growth hormone secretion | positive regulation of long-term synaptic potentiation | protein serine/threonine kinase activity | reproduction | negative regulation of transport | G-protein coupled receptor signaling pathway | protein modification process | regulation of synapse structure or activity | regulation of peptide transport | modulation of chemical synaptic transmission | macromolecule modification | molecular function regulator | locomotion | response to nitrogen compound | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of secretion by cell | positive regulation of neuron projection development | multicellular organism development | cell migration | regulation of synaptic transmission, glutamatergic | phosphorus metabolic process | learning or memory | mammary gland development | regulation of catalytic activity | regulation of hormone levels | regulation of hormone secretion | nonassociative learning | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | nervous system process | neuromuscular junction development | adult locomotory behavior | response to ammonium ion | regulation of synapse organization | enzyme linked receptor protein signaling pathway | positive regulation of cell projection organization | vesicle-mediated transport | synapse organization | positive regulation of hydrolase activity | behavioral response to cocaine | positive regulation of cell differentiation | cognition | regulation of Rho protein signal transduction | cell proliferation | locomotory behavior | negative regulation of peptide hormone secretion | phosphorylation | parental behavior | regulation of GTPase activity | positive regulation of dendritic spine development | response to xenobiotic stimulus | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | smooth muscle cell migration | positive regulation of dendrite development | positive regulation of molecular function | multicellular organism reproduction | maternal process involved in parturition | multicellular organismal response to stress | regulation of cell morphogenesis involved in differentiation | fear response | protein metabolic process | muscle cell migration | response to organic substance | gland development | Rho protein signal transduction | lactation | response to mechanical stimulus | regulation of intracellular signal transduction | anatomical structure development | regulation of dendrite morphogenesis | cell surface receptor signaling pathway | positive regulation of neurogenesis | reproductive behavior | metabolic process | positive regulation of cell development | regulation of protein localization to plasma membrane | regulation of body fluid levels | smooth muscle cell proliferation | Ras guanyl-nucleotide exchange factor activity | regulation of secretion | behavior | positive regulation of cell death | body fluid secretion | protein kinase activity | organic substance metabolic process | animal organ development | positive regulation of programmed cell death | response to alkaloid | regulation of postsynapse organization | memory | adult behavior | regulation of dendrite development | regulation of cell communication | muscle cell proliferation | regulation of dendritic spine development | signaling | response to organic cyclic compound | cellular protein metabolic process | enzyme regulator activity | regulation of Ras protein signal transduction | regulation of nervous system development | regulation of developmental process | kinase activity | developmental process | behavioral defense response | cellular protein modification process | regulation of transport | Ras protein signal transduction | response to organonitrogen compound | response to anesthetic | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of synaptic plasticity | positive regulation of neuron differentiation | Rac guanyl-nucleotide exchange factor activity | regulation of cell projection organization | cellular metabolic process | regulation of protein localization | regulation of cell death | positive regulation of cell morphogenesis involved in differentiation | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | synapse | cell | nuclear lumen | cytoplasm | intracellular organelle | actin cytoskeleton | postsynapse | nucleoplasm | vesicle | postsynaptic density | extracellular exosome | asymmetric synapse | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | postsynaptic specialization | extracellular space | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular