QuickView for KANK2;jsessionid=452D9F33DDD70EC4AA2CF2B800DB3C5C (gene)

Gene Symbol:

KANK2 Homo sapiens

Full name:

KN motif and ankyrin repeat domains 2

Synonyms:

ANKRD25, MXRA3, NPHS16, PPKWH, SIP, KN motif and ankyrin repeat domain-containing protein 2, SRC-interacting protein, SRC1-interacting protein, ankyrin repeat domain-containing protein 25, kidney ankyrin repeat-containing protein 2, matrix-remodeling-associated protein 3

Genomic Location:

Chr 19: 11135946-11167496

Description:

This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney p...

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This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair.

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Orthologs:

Mus musculus ,  Macaca mulatta ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  HSF1_01 ,  SP1_Q4_01 ,  GGGCGGR_SP1_Q6 ,  SP1_Q6 ,  TGTTTGY_HNF3_Q6 ,  AAAYRNCTG_UNKNOWN ,  SREBP_Q3 ,  SP1_Q6_01 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-219

Cytogenetic Map:

19p13.2

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