QuickView for KARS (gene)
- Gene Symbol:
- KARS
Homo sapiens - Full name:
- lysyl-tRNA synthetase
- Synonyms:
- CMTRIB, DFNB89, KARS1, KARS2, KRS, lysine--tRNA ligase, lysRS, lysine tRNA ligase
- Genomic Location:
- Chr 16: 74219131-74239078
- Description:
-
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternativ...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
16q23.1
GO Molecular Function
ATP adenylyltransferase activity | carboxylic acid binding | nucleic acid binding | ribonucleotide binding | tRNA binding | nucleotide binding | carbohydrate derivative binding | nucleotidyltransferase activity | catalytic activity | aminoacyl-tRNA ligase activity | ATP binding | anion binding | adenyl nucleotide binding | amino acid binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | protein dimerization activity | ligase activity | transferase activity, transferring phosphorus-containing groups | adenylyltransferase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | lysine-tRNA ligase activity | organic acid binding | heterocyclic compound binding | small molecule binding | RNA binding
GO Biological Process
positive regulation of immune response | RNA metabolic process | regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | response to radiation | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to cytokine | RNA processing | intracellular signal transduction | regulation of localization | response to X-ray | regulation of immune system process | negative regulation of cellular process | tRNA aminoacylation | regulation of MAP kinase activity | cellular response to tumor necrosis factor | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | positive regulation of protein secretion | positive regulation of cellular biosynthetic process | cellular process | diadenosine tetraphosphate biosynthetic process | positive regulation of macrophage migration | regulation of cell motility | diadenosine polyphosphate metabolic process | nucleotide metabolic process | positive regulation of immune effector process | positive regulation of macrophage activation | positive regulation of protein kinase activity | regulation of chemotaxis | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | interspecies interaction between organisms | cellular amino acid metabolic process | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | MAPK cascade | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | peptide biosynthetic process | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | leukocyte activation involved in immune response | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | ncRNA processing | positive regulation of cell activation | basophil activation involved in immune response | positive regulation of cytokine secretion | positive regulation of proteolysis | cellular nitrogen compound metabolic process | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | activation of protein kinase activity | nucleotide biosynthetic process | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of cellular response to stress | nitrogen compound metabolic process | regulation of signal transduction | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of granulocyte chemotaxis | regulation of phosphorylation | regulation of gene expression | positive regulation of chemotaxis | positive regulation of secretion | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | basophil activation | positive regulation of p38MAPK cascade | regulation of nitrogen compound metabolic process | regulation of cell migration | small molecule metabolic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | cellular amide metabolic process | tRNA aminoacylation for protein translation | regulation of cellular component movement | positive regulation of cytokine production involved in inflammatory response | positive regulation of hydrolase activity | translation | nucleobase-containing small molecule metabolic process | positive regulation of cell migration | cellular response to cytokine stimulus | regulation of cytokine production involved in inflammatory response | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | protein phosphorylation | positive regulation of macrophage chemotaxis | regulation of leukocyte migration | phosphate-containing compound metabolic process | regulation of macrophage activation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of leukocyte chemotaxis | cell activation involved in immune response | regulation of cytokine production involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of establishment of protein localization | regulation of protein phosphorylation | peptide metabolic process | tRNA processing | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | viral process | carboxylic acid metabolic process | positive regulation of molecular function | tRNA metabolic process | regulation of cytokine secretion | activation of MAPK activity | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of cytokine secretion involved in immune response | positive regulation of cytokine production involved in immune response | regulation of secretion | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | amide biosynthetic process | regulation of cell activation | regulation of protein secretion | positive regulation of leukocyte migration | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | tumor necrosis factor-mediated signaling pathway | regulation of phosphate metabolic process | positive regulation of cytokine secretion involved in immune response | positive regulation of cytokine production | cell activation | positive regulation of MAPK cascade | positive regulation of protein transport | regulation of stress-activated MAPK cascade | regulation of cell communication | signaling | regulation of transcription, DNA-templated | organic acid metabolic process | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | cellular protein modification process | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | ERK1 and ERK2 cascade | heterocycle metabolic process | regulation of macrophage chemotaxis | positive regulation of metabolic process | immune system process | cellular metabolic process | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | positive regulation of cell motility | positive regulation of metallopeptidase activity | regulation of inflammatory response | response to ionizing radiation | positive regulation of signaling | signal transduction | regulation of signaling | regulation of p38MAPK cascade | positive regulation of gene expression | lysyl-tRNA aminoacylation | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | protein-containing complex | plasma membrane | aminoacyl-tRNA synthetase multienzyme complex | mitochondrion | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | cytosol | intracellular | membrane
