QuickView for KAT2A (gene)

Gene Symbol:

KAT2A Homo sapiens

Full name:

lysine acetyltransferase 2A

Synonyms:

GCN5, GCN5L2, PCAF-b, hGCN5, histone acetyltransferase KAT2A, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2, General control of amino acid synthesis, yeast, homolog-like 2, K(lysine) acetyltransferase 2A, STAF97, general control of amino acid synthesis protein 5-like 2, histone acetyltransferase GCN5, hsGCN5

Genomic Location:

Chr 17: 37518655-37526908

Description:

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCCCRNNRTGC_UNKNOWN ,  SP1_Q4_01 ,  TGCGCANK_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  ACTAYRNNNCCCR_UNKNOWN ,  SP1_Q6 ,  ACTWSNACTNY_UNKNOWN ,  EGR1_01 ,  RCGCANGCGY_NRF1_Q6 ,  SP1_Q6_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-155

Cytogenetic Map:

17q21.2

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