QuickView for KAT6A (gene)

Gene Symbol:

KAT6A Homo sapiens

Full name:

lysine acetyltransferase 6A

Synonyms:

MOZ, MRD32, MYST-3, MYST3, RUNXBP2, ZC2HC6A, ZNF220, histone acetyltransferase KAT6A, K(lysine) acetyltransferase 6A, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3, MYST histone acetyltransferase (monocytic leukemia) 3, histone acetyltransferase MYST3, monocytic leukemia zinc finger protein, runt-related transcription factor binding protein 2, zinc finger protein 220

Genomic Location:

Chr 8: 41906154-42028662

Description:

This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation d...

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This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  ARNT_01 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  CATTGTYY_SOX9_B1 ,  CAGCACT_MIR5123P ,  MYB_Q5_01 ,  WTGAAAT_UNKNOWN ,  SOX9_B1 ,  CCTGTGA_MIR513 ,  ATACCTC_MIR202 ,  CACCAGC_MIR138 ,  AGCTCCT_MIR28 ,  TATA_C ,  USF_C ,  CTTTAAR_UNKNOWN ,  SOX5_01 ,  USF_01 ,  ATACTGT_MIR144 ,  NMYC_01 ,  GGCACTT_MIR519E ,  USF_Q6_01 ,  GTTATAT_MIR410 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  AGGCACT_MIR5153P ,  SRY_02 ,  AACTTT_UNKNOWN ,  ERR1_Q2

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-28 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

8p11.21

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