QuickView for KAT6B;jsessionid=9511A93C8E89888DA653BAEE428705BA (gene)

Gene Symbol:

KAT6B Homo sapiens

Full name:

lysine acetyltransferase 6B

Synonyms:

GTPTS, MORF, MOZ2, MYST4, ZC2HC6B, qkf, querkopf, histone acetyltransferase KAT6B, K(lysine) acetyltransferase 6B, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4, MOZ-related factor, MYST histone acetyltransferase (monocytic leukemia) 4, MYST-4, histone acetyltransferase MORF, histone acetyltransferase MOZ2, histone acetyltransferase MYST4, monocytic leukemia zinc finger protein-related factor

Genomic Location:

Chr 10: 76256385-76462645

Description:

The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent t...

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The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HFH3_01 ,  YTATTTTNR_MEF2_02 ,  LHX3_01 ,  NKX62_Q2 ,  S8_01 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  TEF_Q6 ,  YTAATTAA_LHX3_01

Cytogenetic Map:

10q22.2

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