QuickView for KCC2 (gene)

Gene Symbol:

SLC12A5 Homo sapiens

Full name:

solute carrier family 12 member 5

Synonyms:

EIEE34, EIG14, KCC2, hKCC2, solute carrier family 12 member 5, K-Cl cotransporter 2, electroneutral potassium-chloride cotransporter 2, erythroid K-Cl cotransporter 2, neuronal K-Cl cotransporter, solute carrier family 12 (potassium/chloride transporter), member 5

Genomic Location:

Chr 20: 44091245-44122196

Description:

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The en...

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K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  VDR_Q3 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  GCANCTGNY_MYOD_Q6 ,  HFH1_01 ,  GTGACTT_MIR224 ,  ARP1_01 ,  CTAWWWATA_RSRFC4_Q2 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GTACAGG_MIR486 ,  NRSF_01 ,  GGGAGGRR_MAZ_Q6 ,  CDPCR3HD_01 ,  CACCCBINDINGFACTOR_Q6 ,  MEF2_01 ,  GGATTA_PITX2_Q2 ,  RREB1_01 ,  CAGGTG_E12_Q6 ,  TGCGCANK_UNKNOWN ,  GAGCTGG_MIR337 ,  SP3_Q3 ,  MYOD_Q6 ,  MYCMAX_01 ,  CAGNWMCNNNGAC_UNKNOWN ,  ACCAAAG_MIR9 ,  CDPCR1_01 ,  GGGCGGR_SP1_Q6 ,  USF_C ,  GTGCCAA_MIR96 ,  HIF1_Q5 ,  E2F1_Q3_01 ,  RNGTGGGC_UNKNOWN ,  GTGCCTT_MIR506 ,  NMYC_01 ,  YGCGYRCGC_UNKNOWN ,  WGGAATGY_TEF1_Q6 ,  CHOP_01 ,  SMAD4_Q6 ,  CTGCAGY_UNKNOWN ,  MMEF2_Q6 ,  ZF5_B ,  CRX_Q4 ,  HIF1_Q3 ,  CAATGCA_MIR33 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-486 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-505

Cytogenetic Map:

20q13.12

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