QuickView for KCC3 (gene)

Gene Symbol:

SLC12A6 Homo sapiens

Full name:

solute carrier family 12 member 6

Synonyms:

ACCPN, KCC3, KCC3A, KCC3B, solute carrier family 12 member 6, K-Cl cotransporter 3, electroneutral potassium-chloride cotransporter 3, potassium chloride cotransporter 3, potassium chloride cotransporter KCC3a-S3, potassium-chloride transporter-3a, potassium-chloride transporter-3b, solute carrier family 12 (potassium/chloride transporter), member 6, solute carrier family 12 (potassium/chloride transporters), member 6

Genomic Location:

Chr 15: 32309489-32417557

Description:

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple tr...

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This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  USF_Q6 ,  AREB6_02 ,  FOXO4_01 ,  CACGTG_MYC_Q2 ,  AML1_01 ,  P53_02 ,  CAGGTG_E12_Q6 ,  NKX61_01 ,  USF_01 ,  RACCACAR_AML_Q6 ,  AML1_Q6 ,  TTGTTT_FOXO4_01 ,  CTGAGCC_MIR24 ,  USF_02 ,  COREBINDINGFACTOR_Q6 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-24

Cytogenetic Map:

15q14

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