QuickView for KCNA2;jsessionid=4D9EF5A5CB76A48702A9395011A7DC07 (gene)

Gene Symbol:

KCNA2 Homo sapiens

Full name:

potassium voltage-gated channel subfamily A member 2

Synonyms:

EIEE32, HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2, potassium voltage-gated channel subfamily A member 2, potassium channel, voltage gated shaker related subfamily A, member 2, potassium voltage-gated channel, shaker-related subfamily, member 2, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, voltage-gated potassium channel protein Kv1.2, voltage-gated potassium channel subunit Kv1.2

Genomic Location:

Chr 1: 110947299-110949868

Description:

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-rela...

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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  EFC_Q6 ,  YNTTTNNNANGCARM_UNKNOWN ,  IPF1_Q4 ,  AP1_Q6 ,  AAGCAAT_MIR137 ,  NFE2_01 ,  AP1_Q6_01 ,  GTGACGY_E4F1_Q6 ,  AP1_01 ,  BACH2_01 ,  E4F1_Q6 ,  NRF2_Q4 ,  BACH1_01 ,  MYOGENIN_Q6 ,  PAX_Q6 ,  CAGCTG_AP4_Q5 ,  FOXM1_01 ,  AP1_Q4_01 ,  TCF11MAFG_01 ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-137

Cytogenetic Map:

1p13.3

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