QuickView for KCNAB1;jsessionid=3D4D7746C6F752CE93DDD7660CDE2C41 (gene)

Gene Symbol:

KCNAB1 Homo sapiens

Full name:

potassium voltage-gated channel subfamily A member regulatory beta subunit 1

Synonyms:

AKR6A3, KCNA1B, KV-BETA-1, Kvb1.3, hKvBeta3, hKvb3, voltage-gated potassium channel subunit beta-1, K(+) channel subunit beta-1, K+ channel Beta1a chain, potassium channel beta 3 chain, potassium channel beta3 subunit, potassium channel shaker chain beta 1a, potassium channel, voltage gated subfamily A regulatory beta subunit 1, potassium voltage-gated channel, shaker-related subfamily, beta member 1

Genomic Location:

Chr 3: 157321031-157739621

Description:

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-rela...

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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  PU1_Q6 ,  TCANNTGAY_SREBP1_01 ,  TGANNYRGCA_TCF11MAFG_01 ,  CACGTG_MYC_Q2 ,  GGGAGGRR_MAZ_Q6 ,  GTAGGCA_MIR189 ,  CAGGTA_AREB6_01 ,  LFA1_Q6 ,  TTCYRGAA_UNKNOWN ,  HMGIY_Q6 ,  MSX1_01 ,  IK1_01 ,  CTGCAGY_UNKNOWN ,  TGACATY_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ELF1_Q6 ,  HNF6_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-189 ,  Predicted Gene Targets for miR-30-3p

Cytogenetic Map:

3q25.31

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