QuickView for KCNJ3 (gene)

Gene Symbol:

KCNJ3 Homo sapiens

Full name:

potassium voltage-gated channel subfamily J member 3

Synonyms:

GIRK1, KGA, KIR3.1, G protein-activated inward rectifier potassium channel 1, GIRK-1, inward rectifier K(+) channel Kir3.1, inward rectifier K+ channel KIR3.1, potassium channel, inwardly rectifying subfamily J member 3, potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e, potassium inwardly-rectifying channel, subfamily J, member 3

Genomic Location:

Chr 2: 155263339-155421260

Description:

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is ...

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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTATTAT_MIR3693P ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  ACTTTAT_MIR1425P ,  TAGCTTT_MIR9 ,  GTGCAAA_MIR507 ,  TAATGTG_MIR323 ,  TITF1_Q3 ,  NKX25_02 ,  FOXM1_01 ,  AACTTT_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-410

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Cytogenetic Map:

2q24.1

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