QuickView for KCNMB2 (gene)

Gene Symbol:

KCNMB2 Homo sapiens

Full name:

potassium calcium-activated channel subfamily M regulatory beta subunit 2

Synonyms:

calcium-activated potassium channel subunit beta-2, BK channel beta subunit 2, BK channel subunit beta-2, MaxiK channel beta 2 subunit, MaxiK channel beta-subunit 2, big potassium channel beta subunit 2, charybdotoxin receptor subunit beta-2, hCG1646471, hbeta2, k(VCA)beta-2, large conductance calcium-activated potassium channel beta 2 subunit, large-conductance Ca2+-activated K+ channel beta2 subunit, potassium channel subfamily M regulatory beta subunit 2, potassium large conductance calcium-activated channel, subfamily M, beta member 2, slo-beta-2

Genomic Location:

Chr 3: 179736918-180044911

Description:

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which d...

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MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GNCF_01 ,  CTACTGT_MIR199A ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TGACCTY_ERR1_Q2 ,  TGCAAAC_MIR452 ,  PXR_Q2 ,  EVI1_02 ,  ACCAAAG_MIR9 ,  ATATGCA_MIR448 ,  BRN2_01 ,  YNGTTNNNATT_UNKNOWN ,  TGACCTTG_SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-452

Cytogenetic Map:

3q26.32

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