QuickView for KCNN4 (gene)

Gene Symbol:

KCNN4 Homo sapiens

Full name:

potassium calcium-activated channel subfamily N member 4

Synonyms:

DHS2, IK, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4, intermediate conductance calcium-activated potassium channel protein 4, SKCa 4, SKCa4, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, putative Gardos channel, putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel, small conductance calcium-activated potassium channel 4

Genomic Location:

Chr 19: 48962525-48977249

Description:

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. Thi...

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The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  TGGNNNNNNKCCAR_UNKNOWN ,  AML_Q6 ,  CACGTG_MYC_Q2 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  CACCCBINDINGFACTOR_Q6 ,  GGGYGTGNY_UNKNOWN ,  AP1FJ_Q2 ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  AP1_Q4 ,  AP1_Q2 ,  SMAD_Q6 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15

Cytogenetic Map:

19q13.31

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