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QuickView for KDM5D (gene)


Gene Symbol:
KDM5D Homo sapiens Homo sapiens
Full name:
lysine demethylase 5D
Synonyms:
HY, HYA, JARID1D, SMCY, lysine-specific demethylase 5D, H-Y, Jumonji, AT rich interactive domain 1D (RBP2-like), SMC homolog, Y chromosome, Smcy homolog, Y-linked, histocompatibility Y antigen, histone demethylase JARID1D, jumonji/ARID domain-containing protein 1D, lysine (K)-specific demethylase 5D, protein SmcY, selected mouse cDNA on Y, human homolog of
Genomic Location:
Chr Y: 20326689-20366212
Description:
This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants.
Orthologs:
Mus musculus Pan troglodytes Rattus norvegicus
External Links:
Entrez Gene
Cytogenetic Map:
chr Y
Yq11.223





GO Molecular Function

RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | cation binding | hormone receptor binding | nucleic acid binding | signaling receptor binding | demethylase activity | histone demethylase activity (H3-trimethyl-K4 specific) | methylated histone binding | catalytic activity | chromatin binding | modification-dependent protein binding | androgen receptor binding | DNA binding | nuclear hormone receptor binding | histone demethylase activity (H3-K4 specific) | histone demethylase activity | ion binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | transcription factor binding | dioxygenase activity | histone binding | steroid hormone receptor binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity

GO Biological Process

RNA metabolic process | adaptive immune response | antigen processing and presentation | T cell antigen processing and presentation | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | histone modification | cellular process | chromatin organization | protein demethylation | negative regulation of nucleic acid-templated transcription | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | regulation of intracellular steroid hormone receptor signaling pathway | demethylase activity | cellular nitrogen compound biosynthetic process | histone demethylase activity (H3-trimethyl-K4 specific) | cellular nitrogen compound metabolic process | negative regulation of metabolic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | nitrogen compound metabolic process | regulation of signal transduction | leukocyte mediated immunity | regulation of gene expression | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | histone demethylase activity (H3-K4 specific) | histone demethylase activity | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | T cell mediated immunity | regulation of androgen receptor signaling pathway | regulation of RNA metabolic process | histone demethylation | protein metabolic process | DNA-binding transcription factor activity | metabolic process | regulation of RNA biosynthetic process | histone H3-K4 demethylation | oxidation-reduction process | negative regulation of transcription, DNA-templated | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | dioxygenase activity | transcription, DNA-templated | histone H3-K4 demethylation, trimethyl-H3-K4-specific | regulation of cell communication | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | histone lysine demethylation | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | heterocycle metabolic process | demethylation | chromosome organization | immune system process | cellular metabolic process | oxidoreductase activity | regulation of signaling | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | catalytic complex | fibrillar center | cell | nuclear lumen | nucleolus | intracellular organelle | histone methyltransferase complex | protein-containing complex | methyltransferase complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular