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QuickView for KIT (gene)


Gene Symbol:
KIT Homo sapiens Homo sapiens
Full name:
KIT proto-oncogene receptor tyrosine kinase
Synonyms:
C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, c-Kit protooncogene, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Genomic Location:
Chr 4: 55218852-55301638
Description:
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors,...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 4
4q12





GO Molecular Function

cytokine binding | guanyl-nucleotide exchange factor activity | transmembrane receptor protein tyrosine kinase activity | GTPase binding | cation binding | transmembrane signaling receptor activity | enzyme binding | ribonucleotide binding | stem cell factor receptor activity | nucleotide binding | carbohydrate derivative binding | Ras GTPase binding | molecular function regulator | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | signaling receptor activity | purine nucleotide binding | phosphatidylinositol 3-kinase activity | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | protein tyrosine kinase activity | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | transferase activity | small GTPase binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | protease binding | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | lysosome localization | response to radiation | regulation of muscle system process | positive regulation of locomotion | actin filament-based process | guanyl-nucleotide exchange factor activity | exocytosis | detection of stimulus | response to cytokine | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | immune response-regulating signaling pathway | glycosphingolipid metabolic process | developmental process involved in reproduction | intracellular signal transduction | ovarian follicle development | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | somatic stem cell population maintenance | gonad development | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | female gonad development | peptidyl-amino acid modification | erythrocyte homeostasis | transmembrane receptor protein tyrosine kinase activity | phosphatidylinositol metabolic process | actin cytoskeleton organization | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to hormone | myeloid cell differentiation | regulation of cell shape | negative regulation of cellular process | cellular response to stem cell factor stimulus | positive regulation of developmental process | regulation of MAP kinase activity | response to metal ion | bone development | cell differentiation | male gamete generation | detection of mechanical stimulus involved in sensory perception | defense response | response to erythropoietin | nervous system development | regulation of smooth muscle contraction | epithelial cell migration | neurogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | positive regulation of cellular component movement | generation of neurons | B cell differentiation | sensory perception of mechanical stimulus | phospholipid metabolic process | intracellular transport | positive regulation of phosphatidylinositol 3-kinase activity | cellular process | secretion | lymphocyte differentiation | leukocyte degranulation | establishment of organelle localization | regulation of cell motility | localization | lymphoid progenitor cell differentiation | negative regulation of signaling | visual learning | regulation of neuronal synaptic plasticity | reproductive system development | epithelium migration | immune system development | multicellular organismal reproductive process | learning | stem cell population maintenance | positive regulation of protein kinase activity | negative regulation of apoptotic process | sphingolipid metabolic process | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | myeloid cell development | response to inorganic substance | establishment of localization in cell | mast cell activation | regulation of cell differentiation | gamete generation | positive regulation of muscle cell differentiation | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | hematopoietic stem cell migration | regulation of metabolic process | organelle localization | mast cell chemotaxis | positive regulation of cellular protein metabolic process | stem cell factor receptor activity | cellular component organization | cellular lipid metabolic process | MAPK cascade | mast cell proliferation | T cell activation | development of primary sexual characteristics | associative learning | regulation of vasculature development | response to stimulus | lamellipodium assembly | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | positive regulation of JAK-STAT cascade | positive regulation of small intestine smooth muscle contraction | leukocyte activation involved in immune response | germ cell development | regulation of cell proliferation | hematopoietic progenitor cell differentiation | pigment cell differentiation | programmed cell death | development of primary female sexual characteristics | melanocyte adhesion | regulation of developmental pigmentation | reproduction | cellular localization | secretion by cell | positive regulation of lipase activity | positive regulation of protein serine/threonine kinase activity | spermatid differentiation | hemopoiesis | cellular component assembly | protein modification process | mast cell migration | modulation of chemical synaptic transmission | embryo development | regulation of phosphatidylinositol 3-kinase activity | macromolecule modification | regulation of steroid metabolic process | cell chemotaxis | activation of protein kinase activity | molecular function regulator | myeloid cell homeostasis | leukocyte migration | tongue development | regulation of nucleic acid-templated transcription | somatic stem cell division | leukocyte differentiation | detection of abiotic stimulus | locomotion | positive regulation of phospholipase C activity | regulation of long-term neuronal synaptic plasticity | cellular response to hormone stimulus | response to light stimulus | regulation of cell projection assembly | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | cell migration | regulation of MAPK cascade | phosphorus metabolic process | learning or memory | leukocyte mediated immunity | regulation of muscle contraction | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | embryonic hemopoiesis | regulation of phosphorylation | regulation of gene expression | nervous system process | myeloid leukocyte differentiation | mast cell degranulation | cell projection assembly | stem cell division | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of smooth muscle cell differentiation | developmental pigmentation | positive regulation of Notch signaling pathway | mast cell mediated immunity | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of Notch signaling pathway | enzyme linked receptor protein signaling pathway | positive regulation of cell projection organization | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | phosphatidylinositol 3-kinase activity | positive regulation of smooth muscle cell differentiation | pigmentation | positive regulation of hydrolase activity | positive regulation of cell differentiation | cognition | homeostasis of number of cells | stem cell differentiation | glycolipid metabolic process | positive regulation of cell migration | positive regulation of long-term neuronal synaptic plasticity | cellular response to cytokine stimulus | B cell activation | cell proliferation | leukocyte proliferation | response to cadmium ion | cell division | regulation of cellular protein metabolic process | phosphorylation | regulation of bile acid metabolic process | regulated exocytosis | digestive tract development | regulation of phospholipase activity | Kit signaling pathway | cytokine production involved in immune response | megakaryocyte differentiation | programmed cell death involved in cell development | protein phosphorylation | positive regulation of pseudopodium assembly | immature B cell differentiation | phosphate-containing compound metabolic process | sensory organ development | lipid phosphorylation | regulation of lipid kinase activity | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of smooth muscle contraction | positive regulation of colon smooth muscle contraction | positive regulation of tyrosine phosphorylation of STAT protein | inflammatory response | cell activation involved in immune response | sensory perception of sound | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | lipid modification | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | glycerolipid metabolic process | regulation of RNA metabolic process | regulation of phospholipid metabolic process | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | lymphocyte activation | protein tyrosine kinase activity | regulation of phospholipase C activity | positive regulation of molecular function | multicellular organism reproduction | activation of MAPK activity | cytokine production | lamellipodium organization | T cell differentiation | development of primary male sexual characteristics | positive regulation of pyloric antrum smooth muscle contraction | cellular response to thyroid hormone stimulus | protein metabolic process | positive regulation of protein modification process | response to organic substance | visual behavior | digestive system development | epithelial cell proliferation | regulation of JAK-STAT cascade | regulation of kinase activity | male sex differentiation | response to mechanical stimulus | detection of stimulus involved in sensory perception | myeloid progenitor cell differentiation | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | membrane lipid metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | embryonic organ development | male gonad development | dendritic cell cytokine production | actin cytoskeleton reorganization | Ras guanyl-nucleotide exchange factor activity | behavior | cell adhesion | immune response | protein kinase activity | positive regulation of muscle contraction | positive regulation of cellular component biogenesis | organic substance metabolic process | maintenance of cell number | cell death | animal organ development | epithelial cell-cell adhesion | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulation of phosphate metabolic process | spermatid development | cytoskeleton organization | detection of mechanical stimulus | cell-cell adhesion | positive regulation of phospholipase activity | cell activation | positive regulation of MAPK cascade | detection of mechanical stimulus involved in sensory perception of sound | sensory perception | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | melanocyte migration | cell development | positive regulation of phosphorylation | cellular protein metabolic process | phosphatidylinositol phosphorylation | positive regulation of MAP kinase activity | positive regulation of plasma membrane bounded cell projection assembly | reproductive structure development | regulation of nervous system development | positive regulation of gastro-intestinal system smooth muscle contraction | regulation of developmental process | melanocyte differentiation | glycerophospholipid metabolic process | regulation of pseudopodium assembly | germ cell migration | kinase activity | developmental process | organelle organization | regulation of muscle cell differentiation | erythrocyte differentiation | Fc receptor signaling pathway | spermatogenesis | response to thyroid hormone | cellular protein modification process | tube development | carbohydrate derivative metabolic process | positive regulation of lipid kinase activity | mast cell cytokine production | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of vascular smooth muscle cell differentiation | regulation of synaptic plasticity | mast cell differentiation | positive regulation of lipid metabolic process | regulation of cell projection organization | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | female sex differentiation | ameboidal-type cell migration | cellular response to organic substance | regulation of cell death | sex differentiation | ectopic germ cell programmed cell death | megakaryocyte development | positive regulation of cell motility | erythropoietin-mediated signaling pathway | negative regulation of cell death | chemotaxis | cellular response to erythropoietin | sexual reproduction | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | integral component of membrane | cytoplasmic side of plasma membrane | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | cytoplasmic side of membrane | mast cell granule | intrinsic component of membrane | external side of plasma membrane | cytoplasm | acrosomal vesicle | intracellular organelle | receptor complex | cell-cell junction | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | vacuole | vesicle | lytic vacuole | integral component of plasma membrane | extracellular region | membrane-bounded organelle | organelle | lysosome | extracellular space | cell periphery | intracellular vesicle | cell surface | intracellular | cell junction | membrane | intrinsic component of plasma membrane