QuickView for KMT2C (gene)
- Gene Symbol:
- KMT2C
Homo sapiens - Full name:
- lysine methyltransferase 2C
- Synonyms:
- HALR, KLEFS2, MLL3, histone-lysine N-methyltransferase 2C, ALR-like protein, histone-lysine N-methyltransferase MLL3, histone-lysine N-methyltransferase, H3 lysine-4 specific, homologous to ALR protein, lysine (K)-specific methyltransferase 2C, myeloid/lymphoid or mixed-lineage leukemia protein 3
- Genomic Location:
- Chr 7: 151462943-151764023
- Description:
-
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone m...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
7q36.1
GO Molecular Function
histone-lysine N-methyltransferase activity | lysine N-methyltransferase activity | protein methyltransferase activity | cation binding | nucleic acid binding | S-adenosylmethionine-dependent methyltransferase activity | catalytic activity | transferase activity, transferring acyl groups | histone methyltransferase activity (H3-K4 specific) | DNA binding | histone methyltransferase activity | ion binding | organic cyclic compound binding | transcription coactivator activity | protein binding | N-methyltransferase activity | transferase activity | histone binding | protein-lysine N-methyltransferase activity | methyltransferase activity | transcription coregulator activity | metal ion binding | heterocyclic compound binding | RNA binding
GO Biological Process
RNA metabolic process | positive regulation of macromolecule biosynthetic process | peptidyl-amino acid modification | regulation of immune system process | histone modification | histone-lysine N-methyltransferase activity | lysine N-methyltransferase activity | protein methyltransferase activity | positive regulation of cellular biosynthetic process | cellular process | chromatin organization | regulation of megakaryocyte differentiation | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | S-adenosylmethionine-dependent methyltransferase activity | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | cellular nitrogen compound biosynthetic process | histone H3-K4 methylation | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | histone methylation | regulation of gene expression | methylation | histone methyltransferase activity (H3-K4 specific) | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | histone methyltransferase activity | regulation of cellular metabolic process | transcription coactivator activity | regulation of RNA metabolic process | protein metabolic process | peptidyl-lysine methylation | regulation of hemopoiesis | N-methyltransferase activity | metabolic process | regulation of RNA biosynthetic process | peptidyl-lysine modification | nucleobase-containing compound metabolic process | organic substance metabolic process | histone lysine methylation | gene expression | transcription, DNA-templated | covalent chromatin modification | regulation of transcription, DNA-templated | protein-lysine N-methyltransferase activity | cellular protein metabolic process | cellular macromolecule biosynthetic process | protein methylation | regulation of developmental process | methyltransferase activity | organelle organization | cellular protein modification process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | MLL3/4 complex | intracellular organelle | histone methyltransferase complex | protein-containing complex | methyltransferase complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
