QuickView for KPNA1;jsessionid=19E68571AFBE68AA5E33CD7A9E12A451 (gene)

Gene Symbol:

KPNA1 Homo sapiens

Full name:

karyopherin subunit alpha 1

Synonyms:

IPOA5, NPI-1, RCH2, SRP1, importin subunit alpha-5, RAG cohort protein 2, SRP1-beta, importin alpha 5, importin subunit alpha-1, importin-alpha-S1, karyopherin alpha 1 (importin alpha 5), nucleoprotein interactor 1, recombination activating gene cohort 2

Genomic Location:

Chr 3: 123623438-123716474

Description:

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene...

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The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TAATGTG_MIR323 ,  TTGGAGA_MIR5155P_MIR519E ,  GTCAGGA_MIR378 ,  YGCANTGCR_UNKNOWN ,  ATGCTGC_MIR103_MIR107 ,  GCM_Q2 ,  ATACTGT_MIR144 ,  AATGTGA_MIR23A_MIR23B ,  ATAACCT_MIR154 ,  RCGCANGCGY_NRF1_Q6 ,  CACTTTG_MIR520G_MIR520H

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-488 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

3q21.1

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