QuickView for KPNA2 (gene)

Gene Symbol:

KPNA2 Homo sapiens

Full name:

karyopherin subunit alpha 2

Synonyms:

IPOA1, QIP2, RCH1, SRP1-alpha, SRP1alpha, importin subunit alpha-1, RAG cohort protein 1, importin subunit alpha-2, importin-alpha-P1, karyopherin alpha 2 (RAG cohort 1, importin alpha 1), pendulin

Genomic Location:

Chr 17: 63462310-63473432

Description:

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a sho...

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The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  TACTTGA_MIR26A_MIR26B ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

17q24.2

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