QuickView for Karyopherin beta 1 (gene)

Gene Symbol:

KPNB1 Homo sapiens

Full name:

karyopherin subunit beta 1

Synonyms:

IMB1, IPO1, IPOB, Impnb, NTF97, importin subunit beta-1, PTAC97, importin 1, importin 90, importin beta-1 subunit, karyopherin (importin) beta 1, nuclear factor p97, pore targeting complex 97 kDa subunit

Genomic Location:

Chr 17: 43082274-43116003

Description:

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds t...

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Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  SP1_01 ,  CMYB_01 ,  DR3_Q4 ,  GATA1_01 ,  RYTTCCTG_ETS2_B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  AML_Q6 ,  E2F1_Q4_01 ,  ZF5_01 ,  TGTGTGA_MIR377 ,  VDR_Q6 ,  E2F_Q6_01 ,  GTACTGT_MIR101 ,  TAGCTTT_MIR9 ,  SREBP1_Q6 ,  AGGAGTG_MIR483 ,  MAF_Q6 ,  MYCMAX_B ,  E2F1_Q4 ,  GGGAGGRR_MAZ_Q6 ,  GTGTGAG_MIR342 ,  TFIII_Q6 ,  STAT3_02 ,  TCTGATA_MIR361 ,  GCTTGAA_MIR498 ,  TCCCRNNRTGC_UNKNOWN ,  GGGYGTGNY_UNKNOWN ,  CATTTCA_MIR203 ,  E2F_Q6 ,  RREB1_01 ,  EGR_Q6 ,  GCGCCTT_MIR525_MIR524 ,  E2F_Q4 ,  CCAWYNNGAAR_UNKNOWN ,  AACYNNNNTTCCS_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  GTGCCAA_MIR96 ,  HIF1_Q5 ,  E2F1_Q3_01 ,  SPZ1_01 ,  GATA2_01 ,  E2F_Q4_01 ,  AHR_01 ,  E2F1DP1RB_01 ,  IK2_01 ,  WTTGKCTG_UNKNOWN ,  SREBP_Q3 ,  GTGGGTGK_UNKNOWN ,  AAGCACT_MIR520F ,  CTTTGT_LEF1_Q2 ,  CACBINDINGPROTEIN_Q6 ,  PAX4_03 ,  E2F_Q3 ,  PPARA_02 ,  E2F_Q3_01 ,  ACCATTT_MIR522 ,  PAX4_01 ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-203

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Cytogenetic Map:

17q21.32

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