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QuickView for Klf2 (gene)


Gene Symbol:
KLF2 Homo sapiens Homo sapiens
Full name:
Kruppel like factor 2
Synonyms:
LKLF, Krueppel-like factor 2, Kruppel-like factor 2 (lung), Kruppel-like factor LKLF, lung Kruppel-like factor, lung Kruppel-like zinc finger transcription factor, lung krueppel-like factor
Genomic Location:
Chr 19: 16296651-16299345
Description:
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processe...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 19
19p13.11


Transcripts Names
NM_016270
Protein Names
Q9UKR6
Q9Y5W3
Q9UJS5
Q6IPC4



GO Molecular Function

RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | nucleic acid binding | DNA binding | ion binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | cell morphogenesis | positive regulation of macromolecule biosynthetic process | response to cytokine | response to interleukin-1 | cellular response to cycloheximide | erythrocyte homeostasis | response to cycloheximide | myeloid cell differentiation | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cellular response to tumor necrosis factor | cell differentiation | respiratory tube development | type I pneumocyte differentiation | response to drug | multicellular organism growth | regulation of sprouting angiogenesis | erythrocyte maturation | response to antibiotic | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | cell maturation | developmental growth | positive regulation of reactive oxygen species metabolic process | immune system development | negative regulation of nucleic acid-templated transcription | lung epithelium development | positive regulation of nitrogen compound metabolic process | myeloid cell development | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | response to hydrogen peroxide | regulation of angiogenesis | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | regulation of vasculature development | response to stimulus | respiratory system development | positive regulation of nitric oxide metabolic process | positive regulation of protein metabolic process | response to stress | cellular nitrogen compound biosynthetic process | negative regulation of angiogenesis | response to laminar fluid shear stress | response to peptide | response to alcohol | cellular nitrogen compound metabolic process | cellular response to toxic substance | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | cellular biosynthetic process | embryo development | myeloid cell homeostasis | regulation of nucleic acid-templated transcription | regulation of neurotransmitter levels | response to nitrogen compound | positive regulation of reactive oxygen species biosynthetic process | system development | nitrogen compound metabolic process | cellular response to antibiotic | negative regulation of interleukin-6 production | multicellular organism development | cellular response to oxidative stress | regulation of gene expression | response to ketone | cellular response to stress | cellular response to peptide | negative regulation of cytokine production | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | cellular response to fluid shear stress | regulation of transcription by RNA polymerase II | response to oxidative stress | homeostasis of number of cells | cellular response to cytokine stimulus | biosynthetic process | aromatic compound biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | response to toxic substance | erythrocyte development | cellular response to drug | chordate embryonic development | regulation of cellular metabolic process | regulation of protein metabolic process | homeostatic process | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | negative regulation of sprouting angiogenesis | lung epithelial cell differentiation | DNA-binding transcription factor activity | response to organic substance | cellular stress response to acid chemical | anatomical structure development | metabolic process | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | developmental maturation | negative regulation of transcription, DNA-templated | cellular response to hydrogen peroxide | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | response to reactive oxygen species | gene expression | transcription, DNA-templated | lung development | regulation of reactive oxygen species biosynthetic process | response to fungicide | response to fluid shear stress | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | regulation of transcription from RNA polymerase II promoter in response to stress | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | erythrocyte differentiation | lung cell differentiation | cellular response to interleukin-1 | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | cellular response to laminar fluid shear stress | positive regulation of nitric oxide biosynthetic process | in utero embryonic development | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | response to tumor necrosis factor | cellular response to organic substance | regulation of interleukin-6 production | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular