QuickView for Klf4 (gene)

Gene Symbol:

KLF4 Homo sapiens

Full name:

Kruppel like factor 4

Synonyms:

EZF, GKLF, Krueppel-like factor 4, Kruppel-like factor 4 (gut), endothelial Kruppel-like zinc finger protein, epithelial zinc finger protein EZF, gut Kruppel-like factor, gut-enriched krueppel-like factor

Genomic Location:

Chr 9: 109286956-109291576

Description:

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking ...

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This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTGTAT_MIR381 ,  CACTGTG_MIR128A_MIR128B ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  AAGCCAT_MIR135A_MIR135B ,  E2F4DP1_01 ,  VDR_Q6 ,  EGR2_01 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  GTCTTCC_MIR7 ,  RRAGTTGT_UNKNOWN ,  TGCCTTA_MIR124A ,  GGGCGGR_SP1_Q6 ,  E2F1_Q3_01 ,  NCX_01 ,  USF_Q6_01 ,  E2F1DP1RB_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  TTCYNRGAA_STAT5B_01 ,  RORA2_01 ,  TACAATC_MIR508 ,  STAT5A_01 ,  CDC5_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  E2F_Q3 ,  STAT5A_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-346 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-493-5p

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Cytogenetic Map:

9q31.2

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