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QuickView for Klk5 (gene)


Gene Symbol:
KLK5 Homo sapiens Homo sapiens
Full name:
kallikrein related peptidase 5
Synonyms:
KLK-L2, KLKL2, SCTE, kallikrein-5, kallikrein-like protein 2, stratum corneum tryptic enzyme
Genomic Location:
Chr 19: 56138371-56148156
Description:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expressi...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 19
19q13.41





GO Molecular Function

hydrolase activity | catalytic activity | serine hydrolase activity | protein binding | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | peptidase activity

GO Biological Process

positive regulation of immune response | extracellular structure organization | proteolysis | regulation of immune system process | cell differentiation | positive regulation of antimicrobial humoral response | cellular process | odontogenesis | positive regulation of immune effector process | tissue development | regulation of immune response | regulation of cellular process | epithelium development | cellular component organization | cornification | positive regulation of antimicrobial peptide production | positive regulation of immune system process | regulation of antimicrobial humoral response | regulation of humoral immune response | programmed cell death | extracellular matrix organization | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | animal organ morphogenesis | amelogenesis | regulation of defense response to bacterium | positive regulation of humoral immune response | epidermal cell differentiation | epidermis development | keratinization | skin development | keratinocyte differentiation | odontogenesis of dentin-containing tooth | positive regulation of signal transduction | positive regulation of defense response to bacterium | protein metabolic process | anatomical structure development | metabolic process | organic substance metabolic process | cell death | animal organ development | positive regulation of G-protein coupled receptor protein signaling pathway | serine-type endopeptidase activity | serine-type peptidase activity | regulation of antimicrobial peptide production | anatomical structure formation involved in morphogenesis | regulation of cell communication | endopeptidase activity | anatomical structure morphogenesis | regulation of G-protein coupled receptor protein signaling pathway | developmental process | positive regulation of antibacterial peptide production | epithelial cell differentiation | peptidase activity | extracellular matrix disassembly | positive regulation of signaling | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | secretory vesicle | endomembrane system | vesicle | extracellular region | membrane-bounded organelle | organelle | epidermal lamellar body | extracellular space | lamellar body | cytosol | intracellular vesicle | intracellular