QuickView for Kras (gene)

Gene Symbol:

KRAS Homo sapiens

Full name:

KRAS proto-oncogene, GTPase

Synonyms:

C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2, GTPase KRas, K-Ras 2, K-ras p21 protein, Kirsten rat sarcoma viral oncogene homolog, Kirsten rat sarcoma viral proto-oncogene, PR310 c-K-ras oncogene, c-Ki-ras, c-Kirsten-ras protein, cellular c-Ki-ras2 proto-oncogene, cellular transforming proto-oncogene, oncogene KRAS2, transforming protein p21, v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog

Genomic Location:

Chr 12: 25249447-25295121

Description:

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, du...

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This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Canis lupus familiaris ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  ATGCAGT_MIR217 ,  GTGTTGA_MIR505 ,  GCATTTG_MIR105 ,  TGAGATT_MIR216 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TAGCTTT_MIR9 ,  OSF2_Q6 ,  ATAGGAA_MIR202 ,  GGGAGGRR_MAZ_Q6 ,  AGCATTA_MIR155 ,  TAL1BETAE47_01 ,  GGCAGAC_MIR346 ,  CAGGTG_E12_Q6 ,  GTGCCAA_MIR96 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  ATATGCA_MIR448 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  TCATCTC_MIR143 ,  ACCATTT_MIR522

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-346 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-543

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miRNA binding sites
(Source: miRecords):

hsa-let-7a Targeted Genes

Cytogenetic Map:

12p12.1

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