QuickView for Kv2.1 (gene)

Gene Symbol:

KCNB1 Homo sapiens

Full name:

potassium voltage-gated channel subfamily B member 1

Synonyms:

DRK1, Kv2.1, potassium voltage-gated channel subfamily B member 1, delayed rectifier potassium channel 1, potassium voltage-gated channel, Shab-related subfamily, member 1, voltage-gated potassium channel subunit Kv2.1

Genomic Location:

Chr 20: 47421912-47532588

Description:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume....

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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  DR3_Q4 ,  MYOD_01 ,  VDR_Q3 ,  NGFIC_01 ,  CAGGTG_E12_Q6 ,  SP1_Q4_01 ,  EGR_Q6 ,  E47_01 ,  GCM_Q2 ,  SP1_Q6 ,  RNGTGGGC_UNKNOWN ,  ATATGCA_MIR448 ,  EGR1_01 ,  PPARA_02 ,  SP1_Q2_01 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-448

Cytogenetic Map:

20q13.13

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