QuickView for LAT;jsessionid=A8884CCDB75E8317A825CD3635FA524A (gene)
- Gene Symbol:
- LAT
Homo sapiens - Full name:
- linker for activation of T cells
- Synonyms:
- IMD52, LAT1, pp36, linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, 36 kDa phospho-tyrosine adaptor protein, linker for activation of T cells, transmembrane adaptor, p36-38
- Genomic Location:
- Chr 16: 28903648-28909605
- Description:
-
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adapt...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
STAT4_01 , TGANTCA_AP1_C , ZIC1_01 , RYTTCCTG_ETS2_B , STAT6_02 , GGGAGGRR_MAZ_Q6 , CAGGTA_AREB6_01 , AP4_Q6 , ETS2_B , NERF_Q2
- Cytogenetic Map:
-
16p11.2
GO Molecular Function
guanyl-nucleotide exchange factor activity | kinase binding | GTPase binding | protein kinase binding | enzyme binding | Ras GTPase binding | molecular function regulator | signaling adaptor activity | protein binding, bridging | molecular adaptor activity | protein binding | Ras guanyl-nucleotide exchange factor activity | SH3/SH2 adaptor activity | small GTPase binding
GO Biological Process
positive regulation of immune response | leukocyte homeostasis | lysosome localization | adaptive immune response | guanyl-nucleotide exchange factor activity | exocytosis | immune response-regulating signaling pathway | intracellular signal transduction | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | integrin-mediated signaling pathway | immune response-activating cell surface receptor signaling pathway | T cell receptor signaling pathway | defense response | positive regulation of phosphate metabolic process | intracellular transport | cellular process | secretion | leukocyte degranulation | establishment of organelle localization | localization | positive regulation of protein kinase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | mast cell activation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | organelle localization | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | MAPK cascade | T cell activation | response to stimulus | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | leukocyte activation involved in immune response | cellular localization | secretion by cell | immune response-activating signal transduction | protein modification process | macromolecule modification | molecular function regulator | signaling adaptor activity | nitrogen compound metabolic process | regulation of signal transduction | phosphorus metabolic process | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | regulation of T cell activation | mast cell degranulation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | mast cell mediated immunity | regulation of nitrogen compound metabolic process | vesicle-mediated transport | Fc-epsilon receptor signaling pathway | second-messenger-mediated signaling | homeostasis of number of cells | regulation of cellular protein metabolic process | phosphorylation | regulated exocytosis | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | lymphocyte homeostasis | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | regulation of protein phosphorylation | lymphocyte activation | positive regulation of molecular function | calcium-mediated signaling | activation of immune response | protein metabolic process | positive regulation of protein modification process | regulation of kinase activity | cell surface receptor signaling pathway | metabolic process | Ras guanyl-nucleotide exchange factor activity | immune response | organic substance metabolic process | gene expression | regulation of cell activation | positive regulation of kinase activity | regulation of phosphate metabolic process | SH3/SH2 adaptor activity | antigen receptor-mediated signaling pathway | cell activation | regulation of cell communication | signaling | positive regulation of phosphorylation | cellular protein metabolic process | Fc receptor signaling pathway | cellular protein modification process | Ras protein signal transduction | positive regulation of metabolic process | immune system process | cellular metabolic process | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | immunological synapse | COP9 signalosome | cell | mast cell granule | intrinsic component of membrane | cytoplasm | intracellular organelle | membrane microdomain | cell-cell junction | Golgi apparatus | protein-containing complex | endomembrane system | plasma membrane | membrane raft | vacuole | lytic vacuole | membrane-bounded organelle | nucleus | organelle | lysosome | cell periphery | intracellular | cell junction | membrane
