QuickView for LCK (gene)

Gene Symbol:

LCK Homo sapiens

Full name:

LCK proto-oncogene, Src family tyrosine kinase

Synonyms:

IMD22, LSK, YT16, p56lck, pp58lck, tyrosine-protein kinase Lck, T-lymphocyte specific protein tyrosine kinase p56lck, leukocyte C-terminal Src kinase, lymphocyte cell-specific protein-tyrosine kinase, p56(LSTRA) protein-tyrosine kinase, proto-oncogene tyrosine-protein kinase LCK, t cell-specific protein-tyrosine kinase

Genomic Location:

Chr 1: 32489427-32524353

Description:

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with p...

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This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RYTTCCTG_ETS2_B ,  MAZ_Q6 ,  AML_Q6 ,  STAT6_02 ,  PEA3_Q6 ,  AML1_01 ,  GGGAGGRR_MAZ_Q6 ,  AP4_Q6 ,  TGCTGAY_UNKNOWN ,  STAT5A_03 ,  RACCACAR_AML_Q6 ,  RNGTGGGC_UNKNOWN ,  AML1_Q6 ,  MTF1_Q4 ,  ELK1_01 ,  CTGCAGY_UNKNOWN ,  E2F_Q2 ,  CAGCTG_AP4_Q5 ,  ETS1_B ,  GGGTGGRR_PAX4_03 ,  LBP1_Q6

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Cytogenetic Map:

1p35.2

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