QuickView for LCMT1 (gene)
- Gene Symbol:
- LCMT1
Homo sapiens - Full name:
- leucine carboxyl methyltransferase 1
- Synonyms:
- CGI-68, LCMT, PPMT1, leucine carboxyl methyltransferase 1, [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1, protein phosphatase methyltransferase 1, protein-leucine O-methyltransferase
- Genomic Location:
- Chr 16: 25030548-25097052
- Description:
-
LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
16p12.1
GO Molecular Function
protein methyltransferase activity | S-adenosylmethionine-dependent methyltransferase activity | protein C-terminal carboxyl O-methyltransferase activity | protein carboxyl O-methyltransferase activity | catalytic activity | O-methyltransferase activity | protein binding | transferase activity | methyltransferase activity | protein C-terminal leucine carboxyl O-methyltransferase activity
GO Biological Process
regulation of cell cycle process | regulation of carbohydrate metabolic process | regulation of programmed cell death | negative regulation of cellular process | protein methyltransferase activity | regulation of organelle organization | regulation of chromosome segregation | cellular process | regulation of mitotic nuclear division | regulation of chromosome separation | regulation of cell cycle | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | S-adenosylmethionine-dependent methyltransferase activity | regulation of mitotic cell cycle spindle assembly checkpoint | regulation of mitotic cell cycle phase transition | regulation of cell cycle phase transition | protein C-terminal carboxyl O-methyltransferase activity | protein modification process | macromolecule modification | protein carboxyl O-methyltransferase activity | nitrogen compound metabolic process | O-methyltransferase activity | methylation | cell cycle | C-terminal protein methylation | regulation of mitotic sister chromatid separation | G2/M transition of mitotic cell cycle | mitotic cell cycle phase transition | regulation of cellular metabolic process | cell cycle G2/M phase transition | regulation of mitotic cell cycle | protein metabolic process | regulation of sister chromatid segregation | mitotic cell cycle | regulation of glucose metabolic process | metabolic process | negative regulation of protein complex assembly | organic substance metabolic process | regulation of chromosome organization | regulation of mitotic sister chromatid segregation | cellular protein metabolic process | protein methylation | methyltransferase activity | protein C-terminal leucine carboxyl O-methyltransferase activity | cellular protein modification process | regulation of mitotic metaphase/anaphase transition | cell cycle phase transition | cellular metabolic process | regulation of cell death | regulation of cellular component organization | post-translational protein modification | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
