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QuickView for LDL receptor (gene)


Gene Symbol:
Ldlr Mus musculus Mus musculus
Full name:
low density lipoprotein receptor
Synonyms:
Hlb301, low-density lipoprotein receptor, LDL receptor
Genomic Location:
Chr 9: 21528038-21554363
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

peptide binding | amyloid-beta binding | cation binding | enzyme binding | protein-containing complex binding | very-low-density lipoprotein particle receptor activity | lipoprotein particle binding | amide binding | identical protein binding | lipoprotein particle receptor activity | ion binding | low-density lipoprotein particle receptor activity | low-density lipoprotein particle binding | protein binding | calcium ion binding | protease binding | metal ion binding | cargo receptor activity

GO Biological Process

negative regulation of leukocyte activation | response to extracellular stimulus | regulation of supramolecular fiber organization | response to nutrient levels | negative regulation of immune system process | long-term memory | positive regulation of cellular component organization | regulation of neurogenesis | regulation of cell development | regulation of localization | lipid transport | positive regulation of lipid catabolic process | establishment of localization | regulation of immune system process | negative regulation of cellular process | negative regulation of astrocyte differentiation | cell differentiation | nervous system development | positive regulation of protein catabolic process | neurogenesis | generation of neurons | intracellular transport | sterol metabolic process | positive regulation of cellular biosynthetic process | cellular process | negative regulation of gliogenesis | organic substance catabolic process | localization | negative regulation of microglial cell activation | anion transport | lipoprotein catabolic process | macromolecule localization | intracellular cholesterol transport | intestinal cholesterol absorption | regulation of lysosomal protein catabolic process | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | positive regulation of triglyceride biosynthetic process | regulation of cell differentiation | cellular response to low-density lipoprotein particle stimulus | intestinal lipid absorption | regulation of cellular process | cellular response to lipid | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | negative regulation of astrocyte activation | positive regulation of cellular protein catabolic process | response to stimulus | very-low-density lipoprotein particle receptor activity | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to stress | regulation of phosphatidylcholine catabolic process | cholesterol import | alcohol metabolic process | positive regulation of lipid biosynthetic process | regulation of plasma lipoprotein particle levels | sterol homeostasis | cholesterol homeostasis | cellular localization | organic hydroxy compound transport | negative regulation of metabolic process | regulation of triglyceride metabolic process | regulation of steroid metabolic process | negative regulation of macrophage activation | organic hydroxy compound metabolic process | response to nitrogen compound | system development | nitrogen compound metabolic process | multicellular organism development | positive regulation of inflammatory response | negative regulation of amyloid fibril formation | learning or memory | response to fatty acid | lipid metabolic process | regulation of gene expression | organic substance transport | response to lipid | nervous system process | protein catabolic process | intracellular sterol transport | positive regulation of cellular metabolic process | digestive system process | regulation of phospholipid catabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | positive regulation of lipoprotein particle clearance | amyloid-beta clearance | positive regulation of lysosomal protein catabolic process | vesicle-mediated transport | cognition | regulation of cholesterol metabolic process | intestinal absorption | sterol transport | regulation of cellular protein metabolic process | lipoprotein particle receptor activity | organic anion transport | positive regulation of amyloid-beta clearance | cholesterol transport | response to caloric restriction | plasma lipoprotein particle clearance | regulation of macrophage activation | regulation of cellular metabolic process | regulation of lipid catabolic process | lipoprotein metabolic process | negative regulation of cell activation | regulation of protein metabolic process | homeostatic process | positive regulation of transport | regulation of phospholipid metabolic process | regulation of lipid biosynthetic process | low-density lipoprotein particle receptor activity | cellular response to fatty acid | cellular response to lipoprotein particle stimulus | phospholipid transport | positive regulation of triglyceride metabolic process | protein metabolic process | response to organic substance | import into cell | anatomical structure development | metabolic process | lipid localization | regulation of protein catabolic process | cholesterol metabolic process | regulation of amyloid fibril formation | regulation of amyloid-beta clearance | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | behavior | organic substance metabolic process | negative regulation of gene expression | regulation of cell activation | positive regulation of protein catabolic process in the vacuole | regulation of phosphate metabolic process | memory | negative regulation of protein metabolic process | organonitrogen compound catabolic process | steroid metabolic process | regulation of glial cell differentiation | regulation of gliogenesis | lipid digestion | regulation of endocytosis | receptor-mediated endocytosis involved in cholesterol transport | positive regulation of triglyceride catabolic process | regulation of nervous system development | regulation of developmental process | receptor-mediated endocytosis | developmental process | negative regulation of glial cell differentiation | digestion | regulation of transport | response to organonitrogen compound | negative regulation of supramolecular fiber organization | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | ion transport | cargo receptor activity | regulation of microglial cell activation | sterol import | cellular response to organic substance | regulation of astrocyte differentiation | low-density lipoprotein particle clearance | negative regulation of cell development | regulation of inflammatory response | positive regulation of endocytosis | regulation of triglyceride biosynthetic process | lipid homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | late endosome | somatodendritic compartment | organelle membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | lipoprotein particle | receptor complex | membrane microdomain | apical part of cell | endosome membrane | Golgi apparatus | protein-containing complex | recycling endosome | endomembrane system | plasma membrane | protein-lipid complex | membrane raft | vacuole | vesicle | clathrin-coated pit | lytic vacuole | endosome | extracellular region | membrane-bounded organelle | low-density lipoprotein particle | organelle | PCSK9-LDLR complex | recycling endosome membrane | lysosome | extracellular space | cell periphery | early endosome | plasma lipoprotein particle | basolateral plasma membrane | plasma membrane raft | intracellular vesicle | cell surface | intracellular | caveola | sorting endosome | membrane