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QuickView for LEPR;jsessionid=C1BD63441D4EE3380F48182DE6CCDEA4 (gene)


Gene Symbol:
LEPR Homo sapiens Homo sapiens
Full name:
leptin receptor
Synonyms:
CD295, LEP-R, LEPRD, OB-R, OBR, leptin receptor, OB receptor, huB219
Genomic Location:
Chr 1: 65658906-65875410
Description:
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hema...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Canis lupus familiaris Pan troglodytes Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 1
1p31.3





GO Molecular Function

cytokine binding | peptide binding | peptide hormone binding | transmembrane signaling receptor activity | leptin receptor activity | amide binding | signaling receptor activity | identical protein binding | cytokine receptor activity | hormone binding | protein binding

GO Biological Process

response to cytokine | regulation of carbohydrate metabolic process | establishment of localization | regulation of autophagy | response to hormone | negative regulation of cellular process | cell differentiation | organ growth | generation of precursor metabolites and energy | glucose homeostasis | blood vessel morphogenesis | regulation of bone remodeling | sterol metabolic process | cellular process | lymphocyte differentiation | localization | developmental growth | negative regulation of gluconeogenesis | immune system development | negative regulation of cellular metabolic process | regulation of behavior | regulation of cellular process | leukocyte activation | regulation of metabolic process | organic cyclic compound metabolic process | T cell activation | response to stimulus | vasculature development | regulation of feeding behavior | positive regulation of cold-induced thermogenesis | alcohol metabolic process | multicellular organismal homeostasis | tube morphogenesis | reproduction | cardiovascular system development | negative regulation of metabolic process | hemopoiesis | blood vessel development | leukocyte differentiation | organic hydroxy compound metabolic process | leptin receptor activity | cellular response to hormone stimulus | system development | reproductive process | multicellular organism development | negative regulation of catalytic activity | regulation of catalytic activity | lipid metabolic process | small molecule metabolic process | cytokine-mediated signaling pathway | bone growth | vesicle-mediated transport | cellular response to cytokine stimulus | angiogenesis | leptin-mediated signaling pathway | negative regulation of autophagy | cytokine receptor activity | energy homeostasis | cell communication | regulation of cellular metabolic process | homeostatic process | lymphocyte activation | T cell differentiation | negative regulation of carbohydrate metabolic process | response to organic substance | import into cell | response to leptin | anatomical structure development | cell surface receptor signaling pathway | regulation of glucose metabolic process | metabolic process | cholesterol metabolic process | oxidation-reduction process | regulation of tissue remodeling | chemical homeostasis | endocytosis | organic substance metabolic process | negative regulation of biosynthetic process | animal organ development | cell activation | anatomical structure formation involved in morphogenesis | steroid metabolic process | negative regulation of molecular function | signaling | energy reserve metabolic process | anatomical structure morphogenesis | energy derivation by oxidation of organic compounds | developmental process | tube development | negative regulation of hydrolase activity | regulation of gluconeogenesis | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | circulatory system development | carbohydrate homeostasis | sexual reproduction | phagocytosis | signal transduction | cellular response to leptin stimulus | multicellular organismal process

GO Cellular Component

integral component of membrane | cell | intrinsic component of membrane | external side of plasma membrane | receptor complex | protein-containing complex | plasma membrane | extracellular region | cell periphery | basolateral plasma membrane | cell surface | membrane