QuickView for LIF (gene)

Gene Symbol:

LIF Homo sapiens

Full name:

LIF, interleukin 6 family cytokine

Synonyms:

CDF, DIA, HILDA, MLPLI, leukemia inhibitory factor, D factor, cholinergic differentiation factor, differentiation inhibitory activity, differentiation-inducing factor, differentiation-stimulating factor, hepatocyte-stimulating factor III, human interleukin in DA cells, melanoma-derived LPL inhibitor

Genomic Location:

Chr 22: 28966441-28972748

Description:

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role i...

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The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  PBX1_02 ,  TTTGCAC_MIR19A_MIR19B ,  AGCYRWTTC_UNKNOWN ,  ETS_Q4 ,  MZF1_01 ,  RYTTCCTG_ETS2_B ,  RSRFC4_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  NFAT_Q6 ,  VDR_Q3 ,  AML_Q6 ,  RSRFC4_Q2 ,  TACTTGA_MIR26A_MIR26B ,  TTF1_Q6 ,  PBX1_01 ,  CTAWWWATA_RSRFC4_Q2 ,  E2F1_Q4 ,  ACTGTGA_MIR27A_MIR27B ,  TAAWWATAG_RSRFC4_Q2 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  AR_Q6 ,  OCT1_Q6 ,  CDP_02 ,  YYCATTCAWW_UNKNOWN ,  GGCAGAC_MIR346 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  AGCTCCT_MIR28 ,  TST1_01 ,  CAGGGTC_MIR504 ,  RRAGTTGT_UNKNOWN ,  ATGTTTC_MIR494 ,  RACCACAR_AML_Q6 ,  PTF1BETA_Q6 ,  HMGIY_Q6 ,  TTGTTT_FOXO4_01 ,  GATA4_Q3 ,  IRF7_01 ,  RGAGGAARY_PU1_Q6 ,  TATA_01 ,  TTCYNRGAA_STAT5B_01 ,  TGATTTRY_GFI1_01 ,  STAT5A_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  TTANWNANTGGM_UNKNOWN ,  ETS1_B ,  COREBINDINGFACTOR_Q6 ,  STTTCRNTTT_IRF_Q6 ,  AGGAAGC_MIR5163P ,  IRF2_01 ,  GGGTGGRR_PAX4_03 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-28 ,  Predicted Gene Targets for miR-346 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-504

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Cytogenetic Map:

22q12.2

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