QuickView for LIFR (gene)

Gene Symbol:

LIFR Homo sapiens

Full name:

LIF receptor alpha

Synonyms:

CD118, LIF-R, SJS2, STWS, SWS, leukemia inhibitory factor receptor, CD118 antigen, LIF receptor, leukemia inhibitory factor receptor alpha

Genomic Location:

Chr 5: 38510822-38631253

Description:

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult a...

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This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  RTAAACA_FREAC2_01 ,  TTANTCA_UNKNOWN ,  FOXJ2_02 ,  GATA_C ,  YTATTTTNR_MEF2_02 ,  CTACTGT_MIR199A ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  CTTTGA_LEF1_Q2 ,  TGACCTY_ERR1_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  TCF4_Q5 ,  TATCTGG_MIR488 ,  LEF1_Q6 ,  GGATTA_PITX2_Q2 ,  CTCAGGG_MIR125B_MIR125A ,  ETS2_B ,  GR_Q6 ,  AR_01 ,  ATGTTAA_MIR302C ,  LMO2COM_02 ,  OCT1_03 ,  TGCCAAR_NF1_Q6 ,  ATACTGT_MIR144 ,  GATA1_02 ,  AP1_Q4 ,  RACCACAR_AML_Q6 ,  ELK1_01 ,  WGGAATGY_TEF1_Q6 ,  GATA4_Q3 ,  IK3_01 ,  IK1_01 ,  ER_Q6_01 ,  TGACATY_UNKNOWN ,  CRX_Q4 ,  AAGCACA_MIR218 ,  ATGTAGC_MIR221_MIR222

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

5p13.1

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