QuickView for LIG1;jsessionid=CD74FC213603C0F981022153C60E95B5 (gene)
- Gene Symbol:
- LIG1
Homo sapiens - Full name:
- DNA ligase 1
- Synonyms:
- DNA ligase 1, ligase I, DNA, ATP-dependent, polydeoxyribonucleotide synthase [ATP] 1
- Genomic Location:
- Chr 19: 53310515-53365372
- Description:
-
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Bos taurus , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
19q13.33
GO Molecular Function
cation binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | DNA ligase (ATP) activity | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | DNA binding | purine nucleotide binding | ion binding | organic cyclic compound binding | DNA ligase activity | purine ribonucleoside triphosphate binding | ligase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | cellular process | cell cycle DNA replication | immune system development | DNA replication, Okazaki fragment processing | mitotic DNA replication | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | DNA ligase (ATP) activity | response to stimulus | response to stress | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cellular biosynthetic process | DNA recombination | DNA repair | system development | nitrogen compound metabolic process | multicellular organism development | cellular response to DNA damage stimulus | DNA biosynthetic process | cellular response to stress | cell cycle | V(D)J recombination | biosynthetic process | cell division | lagging strand elongation | aromatic compound biosynthetic process | mismatch repair | DNA strand elongation | DNA ligase activity | base-excision repair | nucleotide-excision repair, DNA gap filling | Okazaki fragment processing involved in mitotic DNA replication | DNA metabolic process | anatomical structure development | mitotic cell cycle | metabolic process | nucleotide-excision repair | nucleobase-containing compound metabolic process | organic substance metabolic process | transcription-coupled nucleotide-excision repair | DNA ligation | anatomical structure morphogenesis | somatic cell DNA recombination | cellular macromolecule biosynthetic process | nuclear DNA replication | developmental process | DNA strand elongation involved in DNA replication | heterocycle metabolic process | immune system process | cellular metabolic process | DNA replication | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
