QuickView for LIG4;jsessionid=CD74FC213603C0F981022153C60E95B5 (gene)

Gene Symbol:

LIG4 Homo sapiens

Full name:

DNA ligase 4

Synonyms:

LIG4S, DNA ligase 4, DNA joinase, DNA ligase IV, DNA repair enzyme, ligase IV, DNA, ATP-dependent, polydeoxyribonucleotide synthase [ATP] 4, polynucleotide ligase, sealase

Genomic Location:

Chr 13: 107657791-107668717

Description:

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross compleme...

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The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

OCT1_05 ,  MYB_Q5_01 ,  MYB_Q3

Cytogenetic Map:

13q33.3

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