QuickView for LIMK (gene)

Gene Symbol:

LIMK1 Homo sapiens

Full name:

LIM domain kinase 1

Synonyms:

LIMK, LIMK-1, LIM domain kinase 1, LIM motif-containing protein kinase

Genomic Location:

Chr 7: 73136092-73174790

Description:

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong ...

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There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTATTAT_MIR3693P ,  CCCAGAG_MIR326 ,  TTANTCA_UNKNOWN ,  ACTGTGA_MIR27A_MIR27B ,  CACCAGC_MIR138 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  NRF2_Q4 ,  AP1_Q4 ,  TTGCCAA_MIR182 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  ERR1_Q2 ,  ATGAAGG_MIR205 ,  CACTTTG_MIR520G_MIR520H ,  TCF11MAFG_01 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-369-3p

Cytogenetic Map:

7q11.23

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