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QuickView for LMNA (gene)


Gene Symbol:
LMNA Homo sapiens Homo sapiens
Full name:
lamin A/C
Synonyms:
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, MADA, PRO1, lamin, 70 kDa lamin, lamin A/C-like 1, mandibuloacral dysplasia type A, prelamin-A/C, renal carcinoma antigen NY-REN-32
Genomic Location:
Chr 1: 154351085-154376502
Description:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuc...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Bos taurus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 1
1q22





GO Molecular Function

structural molecule activity | protein binding

GO Biological Process

nucleus organization | regulation of muscle system process | cellular response to decreased oxygen levels | mitotic nuclear envelope reassembly | positive regulation of cell aging | response to endoplasmic reticulum stress | regulation of cellular localization | muscle tissue development | regulation of localization | regulation of programmed cell death | regulation of cell aging | establishment of localization | negative regulation of cellular process | positive regulation of developmental process | microtubule cytoskeleton organization | cell differentiation | striated muscle cell development | negative regulation of mitochondrion organization | regulation of organelle organization | cardiac cell development | membrane organization | intracellular transport | microtubule-based process | cellular process | regulation of cell motility | localization | protein transport | negative regulation of signaling | establishment or maintenance of microtubule cytoskeleton polarity | negative regulation of mesenchymal cell proliferation | macromolecule localization | endoplasmic reticulum unfolded protein response | negative regulation of apoptotic process | endomembrane system organization | response to hypoxia | negative regulation of release of cytochrome c from mitochondria | establishment of localization in cell | tissue development | muscle structure development | muscle cell differentiation | negative regulation of apoptotic signaling pathway | negative regulation of muscle hypertrophy | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | protein import into nucleus | ventricular cardiac muscle cell development | cellular response to unfolded protein | response to topologically incorrect protein | cellular component organization | cellular response to topologically incorrect protein | response to stimulus | muscle cell development | regulation of cellular protein localization | nuclear envelope reassembly | cellular response to hypoxia | response to stress | intracellular protein transport | regulation of cell proliferation | cardiac muscle tissue development | protein localization to nucleus | cellular localization | nuclear envelope organization | system development | response to oxygen levels | regulation of signal transduction | multicellular organism development | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | organic substance transport | cellular response to stress | cell cycle | negative regulation of cardiac muscle hypertrophy | regulation of protein localization to nucleus | cellular response to oxygen levels | regulation of cell migration | peptide transport | cardiocyte differentiation | regulation of cellular component movement | protein localization to organelle | import into nucleus | negative regulation of extrinsic apoptotic signaling pathway | cardiac muscle cell development | regulation of apoptotic signaling pathway | establishment or maintenance of cell polarity | protein import | regulation of mitochondrion organization | regulation of cardiac muscle hypertrophy in response to stress | striated muscle tissue development | cell communication | heart development | regulation of locomotion | striated muscle cell differentiation | negative regulation of cardiac muscle hypertrophy in response to stress | regulation of cardiac muscle hypertrophy | response to organic substance | IRE1-mediated unfolded protein response | establishment of protein localization to organelle | anatomical structure development | mitotic cell cycle | negative regulation of programmed cell death | cellular protein localization | amide transport | nuclear transport | animal organ development | cytoskeleton organization | negative regulation of cardiac muscle adaptation | establishment of protein localization | cardiac muscle cell differentiation | regulation of cell communication | negative regulation of signal transduction | signaling | cell development | protein localization | response to unfolded protein | cellular macromolecule localization | nucleocytoplasmic transport | regulation of developmental process | regulation of mesenchymal cell proliferation | developmental process | organelle organization | negative regulation of cell proliferation | ventricular cardiac muscle cell differentiation | establishment or maintenance of cytoskeleton polarity | positive regulation of metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | negative regulation of cell death | circulatory system development | regulation of cellular component organization | signal transduction | regulation of signaling | positive regulation of gene expression | multicellular organismal process

GO Cellular Component

intermediate filament | supramolecular fiber | lamin filament | intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | intermediate filament cytoskeleton | endomembrane system | nucleoplasm | nuclear envelope | nuclear speck | nuclear lamina | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane | supramolecular complex | nuclear periphery