QuickView for LOX1 (gene)

Gene Symbol:

OLR1 Homo sapiens

Full name:

oxidized low density lipoprotein receptor 1

Synonyms:

CLEC8A, LOX1, LOXIN, SCARE1, SLOX1, oxidized low-density lipoprotein receptor 1, C-type lectin domain family 8 member A, hLOX-1, lectin-type oxidized LDL receptor 1, ox LDL receptor 1, oxidized low density lipoprotein (lectin-like) receptor 1, oxidized low-density lipoprotein receptor 1, soluble form, scavenger receptor class E, member 1

Genomic Location:

Chr 12: 10202166-10216057

Description:

This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a r...

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This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  FOXJ2_02 ,  AP1_Q6 ,  TTTNNANAGCYR_UNKNOWN ,  ACCAATC_MIR509 ,  AP1_Q6_01 ,  AP1_01 ,  AP1_Q2_01 ,  AP1_Q4_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7

Cytogenetic Map:

12p13.2

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