QuickView for LPHN3 (gene)

Gene Symbol:

ADGRL3 Homo sapiens

Full name:

adhesion G protein-coupled receptor L3

Synonyms:

CIRL3, CL3, LEC3, LPHN3, adhesion G protein-coupled receptor L3, CIRL-3, calcium-independent alpha-latrotoxin receptor 3, latrophilin homolog 3 (cow), latrophilin-3, lectomedin 3

Genomic Location:

Chr 4: 62045434-62620763

Description:

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a lar...

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This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GCANCTGNY_MYOD_Q6 ,  TGAGATT_MIR216 ,  AP2GAMMA_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  ATGTACA_MIR493 ,  ACTTTAT_MIR1425P ,  FAC1_01 ,  SREBP1_Q6 ,  GTGCAAA_MIR507 ,  ATGGYGGA_UNKNOWN ,  AP2ALPHA_01 ,  HEB_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TAGGTCA_MIR192_MIR215 ,  CACCAGC_MIR138 ,  ATGCTGC_MIR103_MIR107 ,  GCAAAAA_MIR129 ,  ATGTTAA_MIR302C ,  KCCGNSWTTT_UNKNOWN ,  CAGTCAC_MIR134 ,  TTGTTT_FOXO4_01 ,  AP4_Q6_01 ,  WTTGKCTG_UNKNOWN ,  GTGGTGA_MIR197 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  GTCTACC_MIR379

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-192 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-379 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-455 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-544

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Cytogenetic Map:

4q13.1

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