QuickView for LRs (gene)

Gene Symbol:

LARS Homo sapiens

Full name:

leucyl-tRNA synthetase

Synonyms:

HSPC192, ILFS1, LARS1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl, leucine--tRNA ligase, cytoplasmic, cytoplasmic leucyl-tRNA synthetase, cytosolic leucyl-tRNA synthetase, leucine tRNA ligase 1, cytoplasmic, leucine translase, proliferation-inducing gene 44

Genomic Location:

Chr 5: 145472782-145542487

Description:

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutatio...

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This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACWWCAANK_UNKNOWN ,  CEBPA_01 ,  MEF2_02 ,  ACTAYRNNNCCCR_UNKNOWN ,  SNACANNNYSYAGA_UNKNOWN ,  WCAANNNYCAG_UNKNOWN

Cytogenetic Map:

5q32

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