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QuickView for LTBP1;jsessionid=3F901DD08F9BA7BF40D992B88479FD7F (gene)


Gene Symbol:
LTBP1 Homo sapiens Homo sapiens
Full name:
latent transforming growth factor beta binding protein 1
Synonyms:
latent-transforming growth factor beta-binding protein 1, LTBP-1, TGF-beta1-BP-1, transforming growth factor beta-1-binding protein 1
Genomic Location:
Chr 2: 33025896-33478080
Description:
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extrac...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
CGTSACG_PAX3_B TGGAAA_NFAT_Q4_01 GATTGGY_NFY_Q6_01 CACTGTG_MIR128A_MIR128B GTATTAT_MIR3693P SMTTTTGT_UNKNOWN GATA1_03 TAL1ALPHAE47_01 TTANTCA_UNKNOWN CREBP1CJUN_01
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2p22.3





GO Molecular Function

transforming growth factor beta binding | structural molecule activity | cytokine binding | transforming growth factor beta-activated receptor activity | cation binding | transmembrane signaling receptor activity | microfibril binding | protein serine/threonine kinase activity | growth factor binding | catalytic activity | signaling receptor activity | ion binding | protein binding | transmembrane receptor protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | calcium ion binding | kinase activity | metal ion binding | extracellular matrix structural constituent

GO Biological Process

regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | transforming growth factor beta-activated receptor activity | cellular process | localization | negative regulation of signaling | macromolecule localization | regulation of cellular process | sequestering of TGFbeta in extracellular matrix | response to stimulus | vasculature development | protein serine/threonine kinase activity | cardiovascular system development | protein modification process | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | blood vessel development | negative regulation of cellular response to transforming growth factor beta stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | phosphorus metabolic process | artery development | coronary vasculature development | extracellular negative regulation of signal transduction | enzyme linked receptor protein signaling pathway | negative regulation of cellular response to growth factor stimulus | sequestering of extracellular ligand from receptor | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | maintenance of protein location | cell communication | transmembrane receptor protein serine/threonine kinase signaling pathway | heart development | regulation of cellular response to growth factor stimulus | ventricular septum development | protein metabolic process | transmembrane receptor protein serine/threonine kinase activity | cardiac ventricle development | negative regulation of transforming growth factor beta receptor signaling pathway | anatomical structure development | cell surface receptor signaling pathway | aorta development | metabolic process | protein kinase activity | organic substance metabolic process | animal organ development | regulation of cell communication | negative regulation of signal transduction | signaling | protein localization | cellular protein metabolic process | kinase activity | developmental process | cardiac septum development | cellular protein modification process | cardiac chamber development | cellular metabolic process | circulatory system development | signal transduction | regulation of signaling | post-translational protein modification | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

supramolecular fiber | intracellular membrane-bounded organelle | extracellular matrix | cell | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | endoplasmic reticulum | protein-containing complex | endomembrane system | endoplasmic reticulum lumen | extracellular region | membrane-bounded organelle | organelle | membrane-enclosed lumen | microfibril | intracellular | supramolecular complex