QuickView for LUM;jsessionid=DF4BF83FABAE68907919B9421139EA4A (gene)

Gene Symbol:

LUM Homo sapiens

Full name:

lumican

Synonyms:

LDC, SLRR2D, lumican, KSPG lumican, keratan sulfate proteoglycan lumican, lumican proteoglycan

Genomic Location:

Chr 12: 90021363-90029673

Description:

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major ...

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This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCANNTGAY_SREBP1_01 ,  CAGGTG_E12_Q6 ,  AHR_Q5 ,  SREBP_Q3 ,  AACTTT_UNKNOWN

Cytogenetic Map:

12q21.33

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