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QuickView for Levofloxacin (compound)

Name: Levofloxacin
Name (isomeric): DB01137
Drug Type: small molecule
Brand: Levoxacin, Mosardal, Nofaxin, Levox, Cravit Ophthalmic, Levokacin, Lesacin, Tavanic, Quixin, Cravit, Reskuin, Iquix, Levaquin, Floxel, Leroxacin, Volequin, Elequine
Category: Anti-Bacterial Agents, Quinolones, Anti-Infective Agents, Urinary, Nucleic Acid Synthesis Inhibitors
CAS number: 100986-85-4
Indication: For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: <i>Corynebacterium</i> species, <i>Staphylococus aureus</i>, <i>Staphylococcus epidermidis</i>, <i>Streptococcus pneumoniae</i>, <i>Streptococcus</i> (Groups C/F/G), Viridans group streptococci, <i>Acinetobacter lwoffii</i>, <i>Haemophilus influenzae</i>, <i>Serratia marcescens</i>.
Levofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levofloxacin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated uri...
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Mechanism of Action: Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.
Absorption: Absorption of ofloxacin after single or multiple doses of 200 to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose.
Protein binding: 24-38% (to plasma proteins)
Biotransformation: Mainly excreted as unchanged drug (87%); undergoes limited metabolism in humans.
Route of elimination: Mainly excreted as unchanged drug in the urine.
Half Life: 6-8 hours
Toxicity: Side effects include disorientation, dizziness, drowsiness, hot and cold flashes, nausea, slurring of speech, swelling and numbness in the face
Affected organisms: Enteric bacteria and other eubacteria
Food interaction:
Take without regard to meals. Take with water, drink lliberally. Taking this product with orange juice can result in reduced quinolone plasma levels.
Drug interaction:
ErythromycinIncreased risk of cardiotoxicity and arrhythmias
PromazineIncreased risk of cardiotoxicity and arrhythmias
DisopyramideIncreased risk of cardiotoxicity and arrhythmias
AnisindioneThe quinolone antibiotic, levofloxacin, may increase the anticoagulant effect of anisindione.
TriflupromazineIncreased risk of cardiotoxicity and arrhythmias
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