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QuickView for Linezolid (compound)

Name: linezolid
PubChem Compound ID: 3929
Molecular formula: C16H20FN3O4
Molecular weight: 337.346 g/mol
Name: linezolid
Name (isomeric): DB00601
Drug Type: small molecule
Brand: Zyvoxid, Zyvox, Linezlid
Category: Protein Synthesis Inhibitors, Anti-Infective Agents, Antibacterial Agents
CAS number: 165800-03-3
Indication: For the treatment of bacterial infections caused by susceptible strains of vancomycin resistant <i>Enterococcus faecium</i>, <i>Staphylococcal aureus</i> (methicillin resistant and susceptible strains), <i>Streptococcus pneumoniae</i>, <i>Streptococcus pyogenes</i>, <i>Streptococcus agalactiae</i>.
Linezolid is a synthetic antibacterial agent of a new class of antibiotics, the oxazolidinones, which has clinical utility in the treatment of infections caused by aerobic Gram-positive bacteria. The in vitro spectrum of activity of linezolid also includes certain Gram-negative bacteria and anaerobic bacteria. Susceptible organisms include methicil...
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Mechanism of Action:
Linezolid is a synthetic antibacterial agent of the oxazolidinone class of antibiotics. It has in vitro activity against aerobic Gram positive bacteria, certain Gram negative bacteria and anaerobic microorganisms. It selectively inhibits bacterial protein synthesis through binding to sites on the bacterial ribosome and prevents the formation of a f...
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Absorption: Linezolid is rapidly and extensively absorbed after oral dosing. Maximum plasma concentrations are reached approximately 1 to 2 hours after dosing, and the absolute bioavailability is approximately 100%.
Protein binding: 31%
Biotransformation: Linezolid is primarily metabolized by oxidation of the morpholine ring, which results in two inactive ring-opened carboxylic acid metabolites: the aminoethoxyacetic acid metabolite (A), and the hydroxyethyl glycine metabolite
Half Life: 4.5-5.5 hours
Toxicity: Clinical signs of acute toxicity lead to decreased activity, ataxia, vomiting and tremors.
Affected organisms: Gram negative and gram positive bacteria
Food interaction:
Take without regard to meals.
Drug interaction:
DobutaminePossible increase of arterial pressure
FenoterolPossible increase of arterial pressure
NorepinephrinePossible increase of arterial pressure
ProcaterolPossible increase of arterial pressure
BrimonidineMAO Inhibitors like linezolid may enhance the hypertensive effect of Alpha2-Agonists (Ophthalmic). The concomitant use of monoamine oxidase inhibitors and ophthalmic alpha2 agonists is contraindicated.
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