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QuickView for Lomefloxacin (compound)
PubChem
| Name: | lomefloxacin |
|---|---|
| PubChem Compound ID: | 11653199 |
| Molecular formula: | C17H19F2N3O3 |
| Molecular weight: | 350.351 g/mol |
DrugBank
Identification
| Name: | lomefloxacin |
|---|---|
| Name (isomeric): | DB00978 |
| Drug Type: | small molecule |
| Synonyms: |
lomefloxacin hydrochloride; Lomefloxacinum [Latin]; LFLX; Lomefloxacine [French]; Lomefloxacino [Spanish]
|
| Brand: | Bareon, Maxaquin |
| Category: | Anti-Infective Agents, Photosensitizing Agents, Anti-Infective Agents, Urinary, Antitubercular Agents |
| CAS number: | 98079-51-7 |
Pharmacology
| Indication: | For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: <i>S.pneumoniae</i>, <i>H.influenzae</i>, <i>S.aureus</i>, <i>P.aeruginosa</i>, <i>E. cloacae</i>, <i>P. mirabilis</i>, <i>C. civersus</i>, <i>S. asprphyticus</i>, <i>E.coli</i>, and <i>K.pneumoniae</i>. |
|---|---|
| Pharmacology: |
Lomefloxacin is a fluoroquinolone antibiotic used to treat chronic bronchitis, as well as complicated and uncomplicated urinary tract infections. It is also used as a prophylactic or preventative treatment to prevent urinary tract infections in patients undergoing transrectal or transurethral surgical procedures. Flouroquinolones such as lomefloxac...
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| Mechanism of Action: |
Lomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. D...
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| Absorption: | Rapid and nearly complete with approximately 95% to 98% of a single oral dose being absorbed. |
| Protein binding: | 10% |
| Biotransformation: | Minimally metabolized although 5 metabolites have been identified in human urine. 65% appears as the parent drug in urine and 9% as the glucuronide metabolite. |
| Route of elimination: | The urinary excretion of lomefloxacin was virtually complete within 72 hours after cessation of dosing, with approximately 65% of the dose being recovered as parent drug and 9% as its glucuronide metabolite. |
| Half Life: | 8 hours |
| Clearance: | 271 mL/min/1.73 m2 [creatinine clearance of 110 mL/min/1.73 m2] 31 mL/min/1.73 m2 [creatinine clearance of 0 mL/min/1.73 m2] |
| Toxicity: | Adverse reactions include peripheral neuropathy, nervousness, agitation, anxiety, and phototoxic events (rash, itching, burning) due to sunlight exposure. |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
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Targets
Enzymes
Transporters
